{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:43:25Z","timestamp":1791495805041,"version":"4.3.4"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:00:00Z","timestamp":1706918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Lipoid proteinosis (LP), also known as Urbach\u2013Wiethe disease, is a rare autosomal recessive genodermatosis, caused by mutations in the ECM1 gene. This results in the deposition of periodic acid\u2013Schiff (PAS)-positive, hyaline-like material on the skin, mucosae and internal organs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To present a case report of LP and a systematic review to synthesize the scientific literature on the management of this uncommon and frequently missed diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We present a case report of a 48-year-old man with LP who exhibited significant improvement after oral acitretin therapy. To address the lack of large case\u2013control studies on LP treatment, we performed a systematic review of the literature following the PRISMA 2020 criteria. The search was conducted in PubMed, Web of Science, Cochrane and Scopus databases from inception until June 2023. To assess the methodological quality of case reports and case series, we used the Joanna Briggs Collaboration critical appraisal tool.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included 25 studies that met eligibility criteria. Data from 44 patients with a histopathologically confirmed diagnosis were analysed. Treatment ranged from systemic therapies (acitretin, etretinate, dimethyl sulfoxide, corticosteroids, penicillamine) to surgical or laser procedures. Regarding methodological quality, the main discrepancies arose in the reporting of participant characteristics and treatment interventions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Low-dose oral acitretin could have potential in managing LP, exhibiting fewer side-effects compared with other therapeutic agents. Further research is needed to establish more comprehensive and evidence-based treatment guidelines.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llae039","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T15:23:53Z","timestamp":1706973833000},"page":"547-555","source":"Crossref","is-referenced-by-count":8,"title":["Advances in treatment for lipoid proteinosis (Urbach\u2013Wiethe disease): a case report and systematic review"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0601-0995","authenticated-orcid":false,"given":"Roc\u00edo C","family":"Bueno-Molina","sequence":"first","affiliation":[{"name":"Departments of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2525-4069","authenticated-orcid":false,"given":"Juan-Carlos","family":"Hern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departments of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Cabrera-Fuentes","sequence":"additional","affiliation":[{"name":"Departments of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Cabrera-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Pathological Anatomy, Virgen del Rocio University Hospital , Seville , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9108-9538","authenticated-orcid":false,"given":"Juli\u00e1n","family":"Conejo-Mir S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departments of Dermatology"},{"name":"Pathological Anatomy, Virgen del Rocio University Hospital , Seville , Spain"},{"name":"Faculty of Medicine, University of Seville , Seville , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6843-5877","authenticated-orcid":false,"given":"Jos\u00e9-Juan","family":"Pereyra-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departments of Dermatology"},{"name":"Pathological Anatomy, Virgen del Rocio University Hospital , Seville , Spain"},{"name":"Faculty of Medicine, University of Seville , Seville , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,3]]},"reference":[{"key":"2024052116320606600_llae039-B1","article-title":"A novel nonsense mutation in exon 9 in the extracellular matrix protein 1 gene associated with lipoid proteinosis: a case report","volume":"7","author":"Ghazawi","year":"2019","journal-title":"SAGE Open Med Case Rep"},{"key":"2024052116320606600_llae039-B2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3109\/09546631003639407","article-title":"Clinical and 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