{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:33:16Z","timestamp":1784755996785,"version":"3.55.0"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"2021 Amorepacific research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The relationship between human papillomavirus (HPV) and Bowen disease (BD) is not fully understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate the differences in HPV detection rates in BD samples across various body regions and analyse the expression patterns of p53, p16 and Ki-67 in relation to HPV presence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Tissue samples from patients diagnosed with BD, confirmed through histopathology, were retrospectively collected. Next-generation sequencing was used for HPV DNA detection. Immunohistochemistry (IHC) for p16, p53 and Ki-67 was performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Out of 109 patients with BD, 21 (19.3%) were HPV-positive. All identified types were \u03b1-HPVs, with HPV-16 being the most common. The HPV detection rate was significantly higher in the pelvic (9\/13, 69%, P &amp;lt; 0.001) and digital (5\/10, 50%, P = 0.02) areas compared with those in the other regions. HPV presence was significantly correlated with p53 negativity (P = 0.002), the p53 \u2018non-overexpression\u2019 IHC pattern (P &amp;lt; 0.001) and p16\u2013p53 immunostain pattern discordance (P &amp;lt; 0.001). Conversely, there was no notable association between HPV presence and p16 positivity, the p16 IHC pattern or Ki-67 expression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our findings suggest the oncogenic role of sexually transmitted and genito-digitally transmitted \u03b1-HPVs in the pathogenesis of BD in pelvic and digital regions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Graphical Abstract<\/jats:title>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llae050","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T01:44:55Z","timestamp":1708134295000},"page":"848-858","source":"Crossref","is-referenced-by-count":10,"title":["Human papillomavirus detection rates in Bowen disease: correlation with pelvic and digital region involvement and\u00a0specific p53 immunostaining patterns"],"prefix":"10.1093","volume":"49","author":[{"given":"Young Chan","family":"Kim","sequence":"first","affiliation":[{"name":"Departments of Dermatology and Pathology, Guro Hospital, Korea University College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Been","family":"Woo","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pathology, Guro Hospital, Korea University College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Na","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pathology, Guro Hospital, Korea University College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pathology, Guro Hospital, Korea University College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-7573","authenticated-orcid":false,"given":"Jiehyun","family":"Jeon","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pathology, Guro Hospital, Korea University College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chungyeul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, Guro Hospital, Korea University College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-2814","authenticated-orcid":false,"given":"Yoo Sang","family":"Baek","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pathology, Guro Hospital, Korea University College of Medicine , 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