{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T12:06:24Z","timestamp":1753272384298,"version":"3.37.3"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"US Department of Veterans Affairs Clinical Sciences R&D Service","award":["IK2 CX002452"],"award-info":[{"award-number":["IK2 CX002452"]}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Fund for Medical Science","award":["2018-I2M-2-002"],"award-info":[{"award-number":["2018-I2M-2-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acitretin, commonly used for severe psoriasis and keratinocyte carcinoma chemoprevention in high-risk patients, is contraindicated in patients with end-stage renal disease (ESRD) on haemodialysis (HD). However, these patients often lack medication choices and in certain clinical scenarios the benefits of acitretin may outweigh the potential risks. We identified 24 patients with ESRD on HD undergoing acitretin treatment from the Duke and Vanderbilt University Medical Centers. While adverse effects were common, they were not a frequent cause of treatment discontinuation among patients. We also found no association between acitretin treatment and hospital admissions or mortality. Lastly, we found statistically significant increases in alkaline phosphatase (ALP; P = 0.03) and total bilirubin (P &amp;lt; 0.001) when patients were receiving acitretin and HD compared with baseline. However, there was no dose dependency or temporal association with acitretin or HD initiation. Based on these preliminary findings, we find that acitretin may safely be used in patients receiving HD, with close monitoring of ALP and bilirubin.<\/jats:p>","DOI":"10.1093\/ced\/llae093","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T17:41:29Z","timestamp":1713202889000},"page":"1052-1055","source":"Crossref","is-referenced-by-count":1,"title":["A report on the safety of acitretin use in patients with renal failure on haemodialysis"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-8378","authenticated-orcid":false,"given":"Paul Jaehoon","family":"Shim","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Arizona College of Medicine , Phoenix, AZ , USA"},{"name":"Department of Dermatology, Duke University School of Medicine , Durham, NC , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica Leigh","family":"Quintos","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Vanderbilt School of Medicine , Nashville, TN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khushnood","family":"Faraz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Duke University School of Medicine , Durham, NC , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle Taylor","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Vanderbilt School of Medicine , Nashville, TN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy\u00a0Jiayue","family":"Petty","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Duke University School of Medicine , Durham, NC , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Bottomley","sequence":"additional","affiliation":[{"name":"CAMS Oxford Institute, University of Oxford , Oxford , UK"},{"name":"Oxford Kidney and Transplant Unit, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust , Oxford , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee Emerson","family":"Wheless","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Vanderbilt School of Medicine , Nashville, TN , USA"},{"name":"Tennessee Valley Healthcare System VA Medical Center , Nashville, TN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-6881","authenticated-orcid":false,"given":"Melodi Javid","family":"Whitley","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Duke University School of Medicine , Durham, NC , 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