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We report on a novel missense variant causing NSML in a patient with an unusual distribution of lentigines and multiple skin cancers. An increased awareness of the potential for malignant change of lentigines in NSML may encourage regular skin surveillance as a mainstay of multidisciplinary management, enabling early diagnosis and management of skin cancers in this group of patients.<\/jats:p>","DOI":"10.1093\/ced\/llae121","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T14:21:29Z","timestamp":1713450089000},"page":"1101-1103","source":"Crossref","is-referenced-by-count":0,"title":["A novel variant in <i>PTPN11<\/i>, c.1277A&amp;gt;G p.(His426Arg), in a patient with Noonan syndrome with multiple lentigines"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9071-9250","authenticated-orcid":false,"given":"Olivia","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Dermatology, Worcestershire Acute Hospitals NHS Trust , Worcester , 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