{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:42:07Z","timestamp":1785300127674,"version":"3.55.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Academic Promotion Programme of Shandong First Medical University","award":["2019LJ002"],"award-info":[{"award-number":["2019LJ002"]}]},{"DOI":"10.13039\/100014103","name":"Key Research and Development Program of Shandong Province","doi-asserted-by":"publisher","award":["2021LCZX07"],"award-info":[{"award-number":["2021LCZX07"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Aseptic pustulosis involves inflammatory skin conditions with nonbacterial pustules on erythema, accompanied by neutrophil and eosinophil infiltration in the epidermis. Dysregulation of the interleukin (IL)-36 pathway leads to neutrophil aggregation and pustule formation. Variants in IL36RN, CARD14, AP1S3, MPO, SERPINA3 and BTN3A3 have been identified in generalized pustular psoriasis (GPP) in the past. Some patients with acrodermatitis continua of Hallopeau (ACH), palmoplantar pustulosis and acute generalized exanthematous pustulosis (AGEP) also exhibit mutations in IL36RN, CARD14 and AP1S3, albeit with regional and population-specific variations. This study aims to explore a shared genetic foundation among those with aseptic pustulosis. We performed Sanger sequencing on six genes in 126 patients with aseptic pustulosis. Genetic analysis identified IL36RN variants strongly associated with ACH, AGEP and subcorneal pustular dermatosis (SPD). Immunohistochemistry revealed elevated inflammatory cytokines in all subtypes. This study establishes a significant association between IL36RN variants and ACH, AGEP and SPD, emphasizing the IL-1\/IL-36\u2013chemokine\u2013neutrophil axis as a common pathogenic mechanism. Targeting this axis holds promise for therapeutic interventions for aseptic pustulosis.<\/jats:p>","DOI":"10.1093\/ced\/llae144","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T07:47:45Z","timestamp":1713858465000},"page":"1217-1226","source":"Crossref","is-referenced-by-count":5,"title":["Genetic analysis of different subtypes of aseptic pustulosis in the Chinese population"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1874-0404","authenticated-orcid":false,"given":"Jing","family":"Chen","sequence":"first","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences , Jinan, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Xue","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences , Jinan, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences , Jinan, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences , Jinan, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3383-1973","authenticated-orcid":false,"given":"Furen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences , Jinan, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"2024091818145437400_llae144-B1","first-page":"287","article-title":"Pathogenesis of sterile pustulosis","volume":"33","author":"Li","year":"2007","journal-title":"Int J Dermatol Venereol"},{"key":"2024091818145437400_llae144-B2","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/jdv.18279","article-title":"Pustular diseases and keratinocyte-myeloid synergy","volume":"36","author":"Christophers","year":"2022","journal-title":"J Eur Acad Dermatol"},{"key":"2024091818145437400_llae144-B3","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.jaci.2016.10.021","article-title":"Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders","volume":"139","author":"Liang","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2024091818145437400_llae144-B4","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.jid.2023.01.023","article-title":"Identification of the BTN3A3 gene as a molecule implicated in generalized pustular \u00adpsoriasis in a Chinese population","volume":"143","author":"Zhang","year":"2023","journal-title":"J Invest Dermatol"},{"key":"2024091818145437400_llae144-B5","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.jaci.2018.06.038","article-title":"Clinical and genetic differences between pustular psoriasis subtypes","volume":"143","author":"Twelves","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"2024091818145437400_llae144-B6","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1038\/jid.2013.44","article-title":"Rare variations in IL36RN in severe adverse drug reactions manifesting as acute generalized exanthematous pustulosis","volume":"133","author":"Navarini","year":"2013","journal-title":"J Invest Dermatol"},{"key":"2024091818145437400_llae144-B7","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/jid.2012.490","article-title":"Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-as sociated pustular phenotypes","volume":"133","author":"Setta-Kaffetzi","year":"2013","journal-title":"J Invest Dermatol"},{"key":"2024091818145437400_llae144-B8","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/humu.22203","article-title":"Mutation analysis of the IL36RN gene in 14 Japanese patients with generalized pustular psoriasis","volume":"34","author":"Farooq","year":"2013","journal-title":"Hum Mutat"},{"key":"2024091818145437400_llae144-B9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00403-015-1611-x","article-title":"Correlation of IL36RN mutation with different clinical features of pustular psoriasis in Chinese patients","volume":"308","author":"Wang","year":"2016","journal-title":"Arch Dermatol Res"},{"key":"2024091818145437400_llae144-B10","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1111\/ajd.13143","article-title":"Upregulation of IL-36 cytokines in folliculitis and eosinophilic pustular folliculitis","volume":"61","author":"Sato","year":"2020","journal-title":"Australas J Dermatol"}],"container-title":["Clinical and Experimental 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