{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:27:46Z","timestamp":1793824066328,"version":"4.6.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Current staging systems have limitations in stratifying high-risk cutaneous squamous cell carcinoma (cSCC). Tumour budding (TB) has emerged as a potential prognostic factor in various cancers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the prognostic significance of TB in predicting lymph node metastases (NM) in cSCC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A comprehensive search of the PubMed, Web of Science, Embase and Cochrane databases was conducted. Studies investigating the association of TB using a 5-bud cutoff and NM in cSCC were included. A meta-analysis was performed using odds ratios (OR) to evaluate the association between TB and NM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Six retrospective studies comprising 793 patients with cSCC were included. The random-effects analysis showed a significant association between high TB (\u2265 5 buds) and NM (OR = 13.29, 95% confidence interval 5.55\u201331.86).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>TB is a promising histopathological feature for predicting NM in cSCC. The results show a strong association between high TB and NM, supporting its utility as a risk factor for NM in cSCC. Its inclusion in clinical practice and cSCC staging might be helpful in the stratification of patients with high-risk cases and to guide optimal management strategies for each patient. However, further investigation is needed to determine standardized reporting guidelines for TB in cSCC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llae155","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T19:25:52Z","timestamp":1714505152000},"page":"1301-1308","source":"Crossref","is-referenced-by-count":4,"title":["Tumour budding as a risk factor for lymph node metastases in cutaneous squamous cell carcinoma: a\u00a0systematic review and meta-analysis"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8469-1942","authenticated-orcid":false,"given":"Pedro","family":"Gil-Pallares","sequence":"first","affiliation":[{"name":"Department of Dermatology, Complejo Hospitalario Universitario de Ferrol , Ferrol ,","place":["Spain"]},{"name":"Universidad de Santiago de Compostela , Santiago de Compostela 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