{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:06:00Z","timestamp":1780700760136,"version":"3.54.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We report the cases of 10 patients with oral squamous cell carcinoma (SCC) post-haematopoietic stem cell transplant (HSCT). Median latency from HSCT to oral SCC diagnosis was 10 years (range: 4\u201317 years), with 90% (9\/10) reporting a history of chronic graft-versus-host disease (cGVHD) and 40% (4\/10) exhibiting active severe manifestations of oral GvHD. Clinical findings at diagnosis included induration, ulceration, tenderness, bleeding, hyperkeratosis, speckling and lymphadenopathy. The tongue and buccal mucosa were the most common sites affected. The disease stage at presentation ranged from T1N0M0 to T4N2M0. Management included surgical resection in 90% (9\/10) of patients with or without chemotherapy and\/or radiotherapy. The median follow-up for the cohort was 1 year, with a 50% (5\/10) mortality rate. SCC-specific mortality was 30% (3\/10). Our data highlight the importance of regular, active oral and cutaneous surveillance of patients post-HSCT in specialized dermatology clinics, irrespective of GvHD severity and length of iatrogenic immunosuppression.<\/jats:p>","DOI":"10.1093\/ced\/llae157","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T09:35:41Z","timestamp":1715592941000},"page":"1413-1419","source":"Crossref","is-referenced-by-count":2,"title":["Secondary oral squamous cell carcinoma following haematopoietic stem cell transplantation"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9137-4830","authenticated-orcid":false,"given":"Faaris","family":"Zaki","sequence":"first","affiliation":[{"name":"Oxford University Hospitals NHS Foundation Trust , Oxford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Shephard","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, University College Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Danby","sequence":"additional","affiliation":[{"name":"Oxford University Hospitals NHS Foundation Trust , Oxford ,","place":["UK"]},{"name":"Anthony Nolan Research Institute , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Pawson","sequence":"additional","affiliation":[{"name":"Oxford University Hospitals NHS Foundation Trust , Oxford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Peniket","sequence":"additional","affiliation":[{"name":"Oxford University Hospitals NHS Foundation Trust , Oxford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine","family":"Sheppard","sequence":"additional","affiliation":[{"name":"Oxford University Hospitals NHS Foundation Trust , Oxford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubeta N","family":"Matin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Churchill Hospital , Oxford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"2024102416193298800_llae157-B1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41409-018-0299-x","article-title":"Clinicopathologic characteristics of secondary squamous cell carcinoma of head and neck in survivors of allogeneic hematopoietic stem cell transplantation for hematologic malignancies","volume":"54","author":"Chaulagain","year":"2019","journal-title":"Bone Marrow Transplant"},{"key":"2024102416193298800_llae157-B2","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1182\/blood-2008-05-158782","article-title":"Solid cancers after allogeneic hematopoietic cell 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