{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:46:36Z","timestamp":1773164796303,"version":"3.50.1"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A potential link between isotretinoin and sexual dysfunction has been reported in various studies. However, such an association has not been explored within the context of a literature review until now.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the methodology and quality of studies investigating this association, and to examine the definitions of sexual dysfunction used.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A scoping review approach was used to identify peer-reviewed research articles. The search terms used were \u2018isotretinoin\u2019, \u2018sexual dysfunction\u2019, \u2018erectile dysfunction\u2019, \u2018ejaculatory disorders\u2019, \u2018decreased libido\u2019, \u2018female sexual interest\u2019, \u2018female arousal disorder\u2019, \u2018libido\u2019, \u2018pelvic pain\u2019, \u2018dyspareunia\u2019, \u2018orgasmic disorder\u2019, \u2018impotence\u2019, \u2018ovaries\u2019, \u2018fertility\u2019 and \u2018menstrual irregularity\u2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 55 peer-reviewed manuscripts were included, consisting of 8 animal studies and 46 human studies with 2420 patients. Of the studies in humans, there were 18 case reports or case series, 2 case\u2013control studies, 4 cross-sectional studies, 6 longitudinal studies, 3 pharmacovigilance reports and 13 cohort studies. The most frequently observed dose range of isotretinoin was 0.5\u20131.0 mg kg\u22121 per day, usually for a duration of 1\u20136 months. More than half of the studies (54%, n = 25) reported a beneficial or neutral effect of isotretinoin on sexual function. The majority of studies (89%, n = 41) were categorized as Oxford Evidenced-Based Medicine level 4.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This scoping review revealed very weak evidence supporting a link between isotretinoin and sexual dysfunction. Notably, the diverse definitions of sexual dysfunction pose a significant challenge for comparative analysis. The authors advocate for a standardized definition of sexual dysfunction and a framework for determining causality in order to contribute to a more comprehensive understanding of the relationship between isotretinoin and sexual dysfunction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llae168","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T11:22:39Z","timestamp":1714821759000},"page":"1396-1404","source":"Crossref","is-referenced-by-count":8,"title":["Exploring the association between isotretinoin and sexual dysfunction: a comprehensive scoping review"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-9179","authenticated-orcid":false,"given":"Eugene","family":"Tan","sequence":"first","affiliation":[{"name":"Skintel , Auckland ,","place":["New Zealand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harriet","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Auckland City Hospital , Te Whatu Ora ,","place":["New Zealand"]},{"name":"Faculty of Medical and Health Sciences, University of Auckland , Auckland ,","place":["New Zealand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3393-6748","authenticated-orcid":false,"given":"Marius","family":"Rademaker","sequence":"additional","affiliation":[{"name":"Clinical Trials New Zealand, Waikato Hospital Campus , Hamilton ,","place":["New Zealand"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,4]]},"reference":[{"key":"2024102416194700200_llae168-B1","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1111\/jdv.16430","article-title":"Comparison of guidelines and consensus articles on the management of patients with acne with oral isotretinoin","volume":"34","author":"Dessinioti","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2024102416194700200_llae168-B2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1440-0960.2012.00947.x","article-title":"Isotretinoin: dose, duration and relapse. 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