{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:27:41Z","timestamp":1740126461975,"version":"3.37.3"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Generalized pustular psoriasis (GPP) is a relapsing\u2013remitting chronic disease characterized by painful pustules with systemic symptoms that has a negative impact on quality of life. The psychosocial and economic burden of this rare condition is not well characterized.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To qualitatively characterize the cumulative burden of GPP on patients\u2019 quality of life and psychosocial wellbeing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective chart review of patients with GPP was performed to collect demographic information, followed by prospective semistructured clinical interviews. Interview transcripts were analysed using thematic analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Three major themes were revealed: (i) burden of having a chronic disease with an unpredictable course, (ii) an inability to fulfil societal roles results in a loss of identity, and (iii) a physician\u2013patient relationship grounded in trust and transparency can be invaluable in helping patients endure chronic disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>GPP has a negative impact on patients\u2019 quality of life and psychosocial wellbeing. Impairments in daily function and mental health primarily affect patients during flares and influence behaviour during periods of quiescence. A strong patient\u2013physician relationship may help mitigate the impact of GPP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llae194","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T18:03:33Z","timestamp":1715623413000},"page":"1362-1366","source":"Crossref","is-referenced-by-count":0,"title":["Qualitative investigation of disease course, characteristics and lived experience of generalized pustular psoriasis"],"prefix":"10.1093","volume":"49","author":[{"given":"Emily A","family":"Parks","sequence":"first","affiliation":[{"name":"East Carolina University Brody School of Medicine , Greenville, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mallory L","family":"Zaino","sequence":"additional","affiliation":[{"name":"Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine , Winston-Salem, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Trettin","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre, Odense University Hospital , Odense ,","place":["Denmark"]},{"name":"Clinical Institute, Health Sciences, University of Southern Denmark , Odense ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R","family":"Feldman","sequence":"additional","affiliation":[{"name":"Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine , Winston-Salem, NC ,","place":["USA"]},{"name":"Department of Dermatology and Allergy Centre, Odense University Hospital , Odense ,","place":["Denmark"]},{"name":"Department of Pathology, Wake Forest School of Medicine , Winston-Salem, NC ,","place":["USA"]},{"name":"Department of Social Sciences & Health Policy, Wake Forest School of Medicine , Winston-Salem, NC 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