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Plantar pain can be debilitating and have a profound impact on quality of life. Current therapeutic options for pain in PC are limited to lifestyle adjustment and mechanical techniques, with a small subgroup of patients benefiting from oral retinoids. This review investigates the pathogenesis of pain in PC and provides a summary of the current and future therapeutic options.<\/jats:p>","DOI":"10.1093\/ced\/llae199","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T20:56:41Z","timestamp":1716929801000},"page":"1510-1517","source":"Crossref","is-referenced-by-count":4,"title":["Pachyonychia congenita: pathogenesis of pain and approaches to treatment"],"prefix":"10.1093","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-8384","authenticated-orcid":false,"given":"Rebecca L","family":"McCarthy","sequence":"first","affiliation":[{"name":"Centre for Cell Biology and Cutaneous Research, Blizard Institute, The Faculty of Medicine and Dentistry, Queen Mary University of London , London ,","place":["UK"]},{"name":"Department of Dermatology, Royal London Hospital, Barts Health NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4156-8634","authenticated-orcid":false,"given":"Marianne","family":"de Brito","sequence":"additional","affiliation":[{"name":"Centre for Cell Biology and Cutaneous Research, Blizard Institute, The Faculty of Medicine and Dentistry, Queen Mary University of London , London ,","place":["UK"]},{"name":"Department of Dermatology, Royal London Hospital, Barts Health NHS Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4084-4836","authenticated-orcid":false,"given":"Edel A","family":"O\u2019Toole","sequence":"additional","affiliation":[{"name":"Centre for Cell Biology and Cutaneous Research, Blizard Institute, The Faculty of Medicine and Dentistry, Queen Mary University of London , London ,","place":["UK"]},{"name":"Department of Dermatology, Royal London Hospital, Barts Health NHS Trust , London 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