{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T02:50:37Z","timestamp":1775011837428,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Childhood-onset psoriasis is often associated with various psychological challenges. Numerous studies have delved into the connection between adult-onset psoriasis and its potential to heighten a patient\u2019s susceptibility to various psychological challenges. However, less has been written about the influence of childhood psoriasis on psychological disorders, particularly anxiety and depression, eating disorders and substance abuse. In this study, we delve into studies that shed light on these associated risks. A systematic literature review was conducted using PubMed, focusing on the psychological impacts of childhood-onset psoriasis. From an initial pool of 313 articles, we utilized Covidence, a specialized software designed for screening and selection, adhering to strict exclusion criteria such as psoriasis in adulthood and incorrect study designs. This process refined our focus to 12 relevant articles, which were critically analysed to understand the psychological comorbidities associated with childhood-onset psoriasis. Our review reveals a significant link between childhood-onset psoriasis and increased instances of depression and anxiety. Notably, children with psoriasis demonstrate higher frequencies of suicidal thoughts and behaviours, as well as a marked propensity for substance abuse and addiction. The study also uncovers a strong connection between psoriasis in children and the development of eating disorders such as anorexia nervosa and bulimia nervosa. Childhood-onset psoriasis significantly affects the psychological wellbeing of children, with heightened risks for depression, anxiety, suicidality, substance abuse and eating disorders. These findings underscore the need for comprehensive management strategies that encompass not only the physical symptoms but also mental health and psychological support for children with psoriasis. Early intervention and regular screenings are crucial in mitigating these risks and improving the quality of life of paediatric patients with psoriasis.<\/jats:p>","DOI":"10.1093\/ced\/llae276","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T18:00:03Z","timestamp":1721325603000},"page":"29-37","source":"Crossref","is-referenced-by-count":7,"title":["Exploring the psychological impact of childhood-onset psoriasis: a systematic review"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8795-6846","authenticated-orcid":false,"given":"Veranca","family":"Shah","sequence":"first","affiliation":[{"name":"Georgetown University School of Medicine , Washington, DC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Larson","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine , Washington, DC ,","place":["USA"]},{"name":"MedStar Georgetown University Hospital Department of Dermatology , Washington, DC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6358-9068","authenticated-orcid":false,"given":"Mohammad","family":"Jafferany","sequence":"additional","affiliation":[{"name":"Central Michigan University College of Medicine\/CMU Medical Education Partners , Saginaw, MI ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"2024122223554164800_llae276-B1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jaad.2019.08.049","article-title":"Joint American Academy of Dermatology\u2013National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis in pediatric patients","volume":"82","author":"Menter","year":"2020","journal-title":"J Am Acad 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