{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:25:36Z","timestamp":1787793936748,"version":"build-2784847793"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T00:00:00Z","timestamp":1722729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hailey\u2013Hailey disease (HHD) is a rare genetic dermatosis characterized by recurrent flaccid vesicles and blisters on erythematous skin in friction areas. The disease follows a chronic relapsing course and has a significant psychological and social impact. Currently, there is no standardized therapeutic regimen for HHD, posing a challenge for dermatologists in managing the condition. We performed this systematic review to investigate the therapeutic role of biologics and small-molecule inhibitors in the treatment of HHD. A systematic search was conducted of the PubMed, Embase, Web of Science, Scopus and Cochrane databases from inception to 1 January 2024. In total, 31 patients with HHD from 18 articles were included in the analysis. Biologics and small-molecule inhibitors were evaluated, including dupilumab, apremilast, upadacitinib, abrocitinib, adalimumab and etanercept. Most reported cases demonstrated clinical improvement after treatment initiation, with few major adverse events. However, some patients experienced recurrences. In conclusion, biologics and small-molecule inhibitors may offer a treatment alternative for patients with refractory HHD, but further confirmation is necessary through large-scale randomized controlled clinical trials.<\/jats:p>","DOI":"10.1093\/ced\/llae298","type":"journal-article","created":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T02:32:31Z","timestamp":1722738751000},"page":"38-45","source":"Crossref","is-referenced-by-count":15,"title":["Treatment of Hailey\u2013Hailey disease with biologics and small-molecule inhibitors: a systematic review"],"prefix":"10.1093","volume":"50","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, First Hospital of Jilin University , Changchun ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Hospital of Jilin University , Changchun ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, First Hospital of Jilin University , Changchun ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,4]]},"reference":[{"key":"2024122223560144900_llae298-B1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/71701","article-title":"Mutations in ATP2C1, encoding a calcium pump, cause Hailey\u2013Hailey disease","volume":"24","author":"Hu","year":"2000","journal-title":"Nat Genet"},{"key":"2024122223560144900_llae298-B2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s40257-019-00477-z","article-title":"Hailey\u2013Hailey disease: an update review with a focus on treatment data","volume":"21","author":"Ben","year":"2020","journal-title":"Am J Clin 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