{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:27:51Z","timestamp":1740126471551,"version":"3.37.3"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A retrospective cohort study was undertaken to examine the management of basal cell carcinoma (BCC) in older patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this study was to identify subgroups where intervention could be minimized, based on frailty and trends in survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All patients aged \u2265 90\u2005years with histologically confirmed BCC during 2017 and 2018 were included within the study (n = 319).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Age was the most significant predictor of survival [hazard ratio (HR) 1.10, 95% confidence interval (CI) 1.04\u20131.17; P = 0.001]. Maximum threshold analysis identified 93\u2005years as the significant age cutpoint. Median survival was 40\u2005months for patients aged \u2264 93\u2005years and 28\u2005months for those aged &amp;gt; 93\u2005years (P = 0.002). Patients with dementia had a worse survival than those without (median survival 25\u2005months vs. 35\u2005months, respectively; HR 1.92, 95% CI 1.18\u20133.13; P = 0.009). There was a statistically significant difference in survival for patients who received treatment for their BCC (n = 294) compared with the untreated cohort (n = 25) (median survival 34\u2005months vs. 21\u2005months, respectively; HR 0.54, 95% CI 0.34\u20130.85; P = 0.007). All other comorbidities examined had no influence on survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study provides evidence in support of active treatment of BCC in individuals aged \u2265 90\u2005years, seen in secondary care. Conservative options may be preferable in patients with dementia or those &amp;gt; 93\u2005years old.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llae344","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T11:22:58Z","timestamp":1723893778000},"page":"120-124","source":"Crossref","is-referenced-by-count":0,"title":["Clinical outcomes of the management of basal cell carcinomas in individuals aged 90\u2005years and over: a retrospective cohort study"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2031-1319","authenticated-orcid":false,"given":"Isabelle","family":"Nicholls","sequence":"first","affiliation":[{"name":"Norfolk and Norwich University Hospital , Norwich ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Moncrieff","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University Hospital , Norwich 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registered skin tumour groups for 2013\u20132019 in England","volume":"188","author":"Van Bodegraven","year":"2023","journal-title":"Br J Dermatol"},{"key":"2024122223552963200_llae344-B2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2340\/00015555-2282","article-title":"Basal cell carcinoma is as common as the sum of all other cancers: implications for treatment capacity","volume":"96","author":"Holm","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"2024122223552963200_llae344-B3","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/annonc\/mdu540","article-title":"The prevalence and outcomes of frailty in older cancer patients: a systematic review","volume":"26","author":"Handforth","year":"2015","journal-title":"Ann Oncol"},{"key":"2024122223552963200_llae344-B4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.4997\/JRCPE.2012.412","article-title":"Frailty and its quantitative clinical evaluation","volume":"42","author":"Moorhouse","year":"2012","journal-title":"J R Coll Physicians Edinb"},{"key":"2024122223552963200_llae344-B5","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0190-9622(84)80334-5","article-title":"Metastatic basal cell carcinoma: report of five cases and review of 170 cases in the literature","volume":"10","author":"Domarus","year":"1984","journal-title":"J Am Acad Dermatol"},{"key":"2024122223552963200_llae344-B6","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1001\/jama.2014.9655","article-title":"Potential overdiagnosis of basal cell carcinoma in older patients with limited life expectancy","volume":"312","author":"Linos","year":"2014","journal-title":"JAMA"},{"author":"Office for National Statistics","key":"2024122223552963200_llae344-B7"},{"issue":"Suppl. 4","key":"2024122223552963200_llae344-B8","article-title":"Clinical outcomes of the management of basal cell carcinomas in individuals aged 90\u2005years and 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