{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:45:19Z","timestamp":1775069119179,"version":"3.50.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T00:00:00Z","timestamp":1725062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Acquired idiopathic generalized anhidrosis (AIGA) is a rare disorder primarily observed in Asian populations, particularly in Japan. Although pulse methylprednisolone therapy is an effective treatment for AIGA, predictors of therapeutic response remain poorly defined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To identify factors that predict the efficacy of pulse methylprednisolone therapy in patients with AIGA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data obtained from 32 patients with AIGA were assessed based on clinical, histopathological and serological examinations. Statistical analyses were conducted to explore predictors of response to pulse methylprednisolone therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The average age of participants was 32.1\u2005years (SD 12.3); 66% were male and 34% female. The response to pulse methylprednisolone therapy was closely associated with the time from the onset to start of therapy (Wilcoxson\u2019s rank sum test, P = 0.02, n = 27), with earlier intervention resulting in a better outcome. Notably, male patients and patients presenting with severe symptoms at diagnosis responded better to treatment. High serum carcinoembryonic antigen (CEA) levels and histological evidence of inflammation around sweat glands also correlated with a positive therapeutic response.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Earlier intervention, elevated serum CEA levels and inflammation around sweat glands are potential indicators of a successful response to pulse methylprednisolone therapy in patients with AIGA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llae363","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T10:01:59Z","timestamp":1725098519000},"page":"125-129","source":"Crossref","is-referenced-by-count":3,"title":["Elevation of serum carcinoembryonic antigen as a possible predictor of response to pulse methylprednisolone in acquired idiopathic generalized anhidrosis"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4849-9383","authenticated-orcid":false,"given":"Tomoki","family":"Sakiyama","sequence":"first","affiliation":[{"name":"Department of Dermatology, Kyoto University Graduate School of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kyoto University Graduate School of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9332-0369","authenticated-orcid":false,"given":"Satoshi","family":"Nakamizo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kyoto University Graduate School of Medicine , Kyoto ,","place":["Japan"]},{"name":"Alliance Laboratory for Advanced Medical Research, Kyoto University Graduate School of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0773-0554","authenticated-orcid":false,"given":"Kenji","family":"Kabashima","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kyoto University Graduate School of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,31]]},"reference":[{"key":"2024122223535793600_llae363-B1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/1346-8138.15666","article-title":"Prognosis after steroid pulse therapy and seasonal effect in acquired idiopathic generalized anhidrosis","volume":"48","author":"Iida","year":"2021","journal-title":"J Dermatol"},{"key":"2024122223535793600_llae363-B2","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/BF00314488","article-title":"Acquired idiopathic generalized anhidrosis: a distinctive clinical syndrome","volume":"235","author":"Murakami","year":"1988","journal-title":"J Neurol"},{"key":"2024122223535793600_llae363-B3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/1346-8138.13649","article-title":"Revised guideline for the diagnosis and treatment of acquired idiopathic generalized anhidrosis in Japan","volume":"44","author":"Munetsugu","year":"2017","journal-title":"J Dermatol"},{"key":"2024122223535793600_llae363-B4","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1212\/01.WNL.0000142036.54112.57","article-title":"Idiopathic pure sudomotor failure: anhidrosis due to deficits in cholinergic transmission","volume":"63","author":"Nakazato","year":"2004","journal-title":"Neurology"},{"key":"2024122223535793600_llae363-B5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jdermsci.2022.10.001","article-title":"Clinicopathological digital image analyses before and after thermal stimulation subdivide acquired idiopathic generalized anhidrosis into inflammatory and non-inflammatory type","volume":"108","author":"Shimoda-Komatsu","year":"2022","journal-title":"J Dermatol Sci"},{"key":"2024122223535793600_llae363-B6","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1111\/jdv.13390","article-title":"Serum carcinoembryonic antigen (CEA) as a clinical marker in acquired idiopathic generalized anhidrosis: a close correlation between serum CEA level and disease activity","volume":"30","author":"Honma","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2024122223535793600_llae363-B7","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/1346-8138.12926","article-title":"Correlation of disease activity and serum level of carcinoembryonic antigen in acquired idiopathic generalized anhidrosis: a case report","volume":"42","author":"Honma","year":"2015","journal-title":"J Dermatol"},{"key":"2024122223535793600_llae363-B8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/1346-8138.15722","article-title":"Clear cell injury associated with reduced expression of carbonic anhydrase II in eccrine glands consistently occurs in patients with acquired idiopathic generalized anhidrosis","volume":"48","author":"Sano","year":"2021","journal-title":"J Dermatol"},{"key":"2024122223535793600_llae363-B9","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1111\/jdv.19284","article-title":"Type 1 interferon signature and cytotoxic T lymphocyte activation targeted against sweat ducts in inflammatory acquired idiopathic generalized anhidrosis","volume":"37","author":"Sano","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"}],"container-title":["Clinical and Experimental 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