{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:08:30Z","timestamp":1780085310147,"version":"3.54.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Folliculitis decalvans (FD) is a chronic neutrophilic scarring alopecia, the exact pathogenesis of which remains unknown. A recent report on the successful use of a novel anti-interleukin (IL)-17 biologic agent to treat FD and the presence of IL-17-secreting mast cells in other types of scarring alopecias point to a distinct pathogenic mechanism in this disease. Our aim was to study and correlate the expression of IL-17 and mast cells in lesional and nonlesional scalp areas of patients with FD, using immunohistochemical techniques. There was significantly greater expression of IL-17 and mast cells in lesional compared with nonlesional scalp areas (P &amp;lt; 0.05). We also found a significantly positive correlation between IL-17 and tryptase-immunolabelled mast cells in nonlesional scalp (r = 0.64), highlighting the role of IL-17-secreting mast cells in \u2018normal-appearing\u2019 sites of FD. These findings suggest that novel treatments targeting both IL-17 and mast cells may be potentially beneficial in controlling the chronic inflammatory status of FD, especially for patients with recalcitrant FD.<\/jats:p>","DOI":"10.1093\/ced\/llae421","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T18:07:56Z","timestamp":1728583676000},"page":"629-631","source":"Crossref","is-referenced-by-count":2,"title":["Evidence of interleukin-17-secreting mast cells in scalp lesions of folliculitis decalvans points to new therapeutic targets in recalcitrant lesions"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8569-9267","authenticated-orcid":false,"given":"Amithis B","family":"Franciozi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-7192","authenticated-orcid":false,"given":"Mirian N","family":"Sotto","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C M","family":"Rivitti-Machado","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Pagliari","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1124-7175","authenticated-orcid":false,"given":"Isabella","family":"Doche","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"2025022416225863100_llae421-B1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1529-8019.2008.00204.x","article-title":"Folliculitis decalvans","volume":"21","author":"Otberg","year":"2008","journal-title":"Dermatol Ther"},{"key":"2025022416225863100_llae421-B2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/exd.13916","article-title":"Folliculitis decalvans is characterized by a persistent, abnormal subepidermal 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biopsies from lichen planopilaris","volume":"44","author":"Miteva","year":"2022","journal-title":"Am J Dermatopathol"},{"key":"2025022416225863100_llae421-B6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/exd.13816","article-title":"IL-17-positive mast cell infiltration in the lesional skin of lichen planopilaris: possible role of mast cells in inducing inflammation and dermal fibrosis in cicatricial alopecia","volume":"29","author":"Hobo","year":"2020","journal-title":"Exp Dermatol"},{"key":"2025022416225863100_llae421-B7","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/cup.14207","article-title":"The presence of mast cells in lichen planopilaris and discoid lupus erythematosus of the scalp: a quantitative study","volume":"49","author":"Shahidi-Dadras","year":"2022","journal-title":"J Cutan Pathol"},{"key":"2025022416225863100_llae421-B8","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/bjd\/ljad273","article-title":"Aberrant expression 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