{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T21:24:14Z","timestamp":1786656254636,"version":"build-2736575974"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Melanoma in young adults significantly impacts the survival of individuals in this age group. There are few studies that analyse melanoma characteristics in young patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe the epidemiological, clinical and histological characteristics of melanoma in young adults and the temporal trends in these characteristics in recent decades.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective observational study was conducted, involving 399 patients with melanoma aged 18\u201344\u2005years, over a 30-year period (1993\u20132022). Patients were divided into two groups based on their date of diagnosis (period 1, 1993\u20132007; period 2, 2008\u20132022).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Age at diagnosis was higher in period 2 than period 1 (34.3 vs. 36.7\u2005years; P &amp;lt; 0.001). Over time, there was a reduction in median thickness (1.0 vs. 0.68\u2005mm; P = 0.01), a rise in melanomas located on the head and neck [n = 15\/230 (6.5%) vs. n = 25\/169 (14.8%)] and extremities [n = 97\/230 (42.2%) vs. n = 76\/169 (45.0%)], and a decrease in melanomas on the trunk [n = 118\/230 (51.3%) vs. n = 68\/169 (40.2%); P = 0.009]. There was also an increase in lentigo maligna [n = 5\/230 (2.3%) vs. n = 5\/169 (3.0%)] and superficial spreading melanomas [n = 176\/230 (76.5%) vs. n = 142\/169 (84.0%)], along with a reduction in nodular types [n = 37\/230 (16.1%) vs. n = 10\/169 (5.9%); P = 0.01]. In comparison with men, women had a higher prevalence of limb melanoma [n = 125\/222 (56.3%) vs. n = 48\/177 (27.1%); P &amp;lt; 0.001] and family history of melanoma [n = 26\/222 (11.7%) vs. n = 9\/177 (5.1%); P = 0.02], thinner melanomas (0.69 vs. 1.10\u2005mm; P = 0.001) and a better prognosis [n = 32\/222 (14.4%) vs. n = 37\/169 (20.9%) deaths; P = 0.01].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Melanoma diagnoses in young adults are occurring at progressively advanced ages, with a rise in melanomas situated on the head and extremities and in histological types linked to prolonged sun exposure. Strategies such as minimizing sun exposure from a young age and encouraging self-examination could lead to improved survival rates.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llae466","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T07:25:53Z","timestamp":1729841153000},"page":"620-628","source":"Crossref","is-referenced-by-count":5,"title":["Epidemiological, clinical and histological characteristics of melanoma in young adults: a 30-year retrospective study (1993\u20132022)"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0694-4757","authenticated-orcid":false,"given":"Bel\u00e9n","family":"Rodr\u00edguez-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid 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