{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T04:44:35Z","timestamp":1749876275055,"version":"3.40.4"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In this retrospective study, we evaluated the efficacy and safety of modified intralesional aciclovir for the treatment of recalcitrant palmoplantar and ungual warts in 14 patients (7 men and 7 women) of mean age 24.5\u2005years (SD 8.19). Modified aciclovir (50\u2005mg mL\u20131) was prepared by mixing 250\u2005mg of lyophilized aciclovir powder with 4\u2005mL of distilled water and 1\u2005mL of 2% lignocaine. Then, this solution was injected into each wart at a dose of 0.1\u2005mL or until blanching occurred. Every 2 weeks, the eschar was pared off and the treatment was repeated until a complete cure was observed, for a maximum of five sessions. After five sessions, 82% (n = 55\/67) of warts showed a complete response, and 18% (n = 12\/67) showed a partial response. Adverse effects reported included lesional tenderness for 2\u20133\u2005days following injection in 23% (n = 3\/13) of patients. Blistering and nail-plate damage were each seen in one patient. Modifying aciclovir treatment by adding lignocaine resulted in an unaltered concentration of aciclovir while maintaining its efficacy. The efficacy and safety were comparable with those reported for previous studies but with greater patient acceptability.<\/jats:p>","DOI":"10.1093\/ced\/llae554","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T18:35:41Z","timestamp":1735842941000},"page":"1009-1013","source":"Crossref","is-referenced-by-count":2,"title":["Modified intralesional aciclovir treatment in the management of recalcitrant palmoplantar and ungual warts: a case series of 14 patients"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-6744","authenticated-orcid":false,"given":"Akash","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences and SUM Hospital , Bhubaneswar ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9171-064X","authenticated-orcid":false,"given":"Parul","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences and SUM Hospital , Bhubaneswar ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhasree","family":"Madhual","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences and SUM Hospital , Bhubaneswar ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maitreyee","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences and SUM Hospital , Bhubaneswar ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"2025042411075677800_llae554-B1","first-page":"25.43","volume-title":"Rook\u2019s Textbook of Dermatology","author":"Sterling","year":"2016","edition":"9th edn"},{"key":"2025042411075677800_llae554-B2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s40257-020-00582-4","article-title":"Management of difficult-to-treat warts: traditional and new approaches","volume":"22","author":"Friedman","year":"2021","journal-title":"Am J Clin Dermatol"},{"key":"2025042411075677800_llae554-B3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/12034754211037998","article-title":"Intralesional acyclovir: a potential therapeutic option for cutaneous warts","volume":"26","author":"Elsayed","year":"2022","journal-title":"J Cutan Med Surg"},{"key":"2025042411075677800_llae554-B4","first-page":"e38781","article-title":"A comparative study of intralesional acyclovir vs immunotherapy for treatment of viral warts","volume":"15","author":"Reddy E","year":"2023","journal-title":"Cureus"},{"key":"2025042411075677800_llae554-B5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00403-024-03001-4","article-title":"Intralesional acyclovir versus intralesional Hepatitis-B vaccine in treatment of resistant plantar warts: a randomized controlled trial","volume":"316","author":"Gharib","year":"2024","journal-title":"Arch Dermatol Res"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llae554\/61322117\/llae554.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/5\/1009\/61322117\/llae554.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/5\/1009\/61322117\/llae554.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T15:08:13Z","timestamp":1745507293000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/50\/5\/1009\/7941834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,2]]},"references-count":5,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,1,2]]},"published-print":{"date-parts":[[2025,4,24]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llae554","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"type":"print","value":"0307-6938"},{"type":"electronic","value":"1365-2230"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,1,2]]}}}