{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T16:41:51Z","timestamp":1750524111367,"version":"3.40.4"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>There are currently no good, evidence-based recommendations for any systemic treatment of erosive lichen planus (ELP). Extracorporeal photopheresis (ECP) may be an effective treatment for recalcitrant forms of this disease. We report three patients with severe ELP who were treated with ECP. Objective clinical responses as assessed by a dermatologist, subjective responses as reported by the patients, and recorded adverse events were monitored. Each patient showed a partial response of cutaneous, oral and genital lesions. Oesophageal lesions were more resistant to the treatment. The findings in the patients reported here, in addition to the 38 other cases reported in the literature, strongly support the value of ECP in the treatment of ELP. ECP may be effective as a salvage treatment option for ELP refractory to current treatments. Owing to the lack of side-effects of ECP, in contrast to other treatments, ECP is a potentially useful treatment option when immunosuppressive drugs are contraindicated.<\/jats:p>","DOI":"10.1093\/ced\/llae555","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T07:59:36Z","timestamp":1736236776000},"page":"1006-1008","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of extracorporeal photopheresis in treating severe erosive lichen planus: a case series"],"prefix":"10.1093","volume":"50","author":[{"given":"Audrey","family":"Loretan","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Geneva University Hospital , Geneva ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Begonia","family":"Cortes","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Geneva University Hospital , Geneva ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"2025042411072768200_llae555-B1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.14219\/jada.2013.10","article-title":"The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review","volume":"145","author":"Fitzpatrick","year":"2014","journal-title":"J Am Dent Assoc"},{"key":"2025042411072768200_llae555-B2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/1523-1747.ep12329711","article-title":"Apoptosis induction of ultraviolet light A and photochemotherapy in cutaneous T-cell lymphoma: relevance to mechanism of therapeutic action","volume":"107","author":"Yoo","year":"1996","journal-title":"J Invest Dermatol"},{"key":"2025042411072768200_llae555-B3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jdermsci.2006.05.004","article-title":"Extracorporeal photopheresis: a focus on apoptosis and cytokines","volume":"43","author":"Bladon","year":"2006","journal-title":"J Dermatol Sci"},{"key":"2025042411072768200_llae555-B4","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0140-6736(05)78932-7","article-title":"Extracorporeal photochemotherapy for chronic erosive lichen planus","volume":"351","author":"Becherel","year":"1998","journal-title":"Lancet"},{"key":"2025042411072768200_llae555-B5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/sj.bmt.1700661","article-title":"Complete remission of lichen-planus-like graft-versus-host disease (GVHD) with extracorporeal photochemotherapy (ECP)","volume":"19","author":"Gerber","year":"1997","journal-title":"Bone Marrow Transplant"},{"key":"2025042411072768200_llae555-B6","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1365-2133.2006.07647.x","article-title":"Treatment of refractory erosive oral lichen planus with extracorporeal photochemotherapy: 12 cases","volume":"156","author":"Guyot","year":"2007","journal-title":"Br J Dermatol"},{"key":"2025042411072768200_llae555-B7","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1610-0387.2005.05759.x","article-title":"Treatment of therapy-resistant erosive oral lichen planus with extracorporeal photopheresis (ECP)","volume":"3","author":"Kunte","year":"2005","journal-title":"J Dtsch Dermatol Ges"},{"key":"2025042411072768200_llae555-B8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.annder.2007.06.010","article-title":"Photopheresis: an alternative therapeutic approach in corticoresistant erosive oral lichen planus","volume":"135","author":"Marchesseau-Merlin","year":"2008","journal-title":"Ann Dermatol Venereol"},{"key":"2025042411072768200_llae555-B9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1365-2133.2011.10378.x","article-title":"Recalcitrant severe erosive cutaneous lichen planus treated with extracorporeal photopheresis monotherapy","volume":"165","author":"Elewa","year":"2011","journal-title":"Br J Dermatol"},{"key":"2025042411072768200_llae555-B10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/09546630902991468","article-title":"Effectiveness of extracorporeal photochemotherapy in the treatment of a case of refractory erosive lichen planus","volume":"21","author":"Zingoni","year":"2010","journal-title":"J Dermatol Treat"},{"key":"2025042411072768200_llae555-B11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.annder.2019.02.011","article-title":"Efficacy of photopheresis in the treatment of erosive lichen planus: a retrospective study","volume":"147","author":"Birckel","year":"2020","journal-title":"Ann Dermatol Venereol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llae555\/61364053\/llae555.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/5\/1006\/61364053\/llae555.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/5\/1006\/61364053\/llae555.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T15:07:37Z","timestamp":1745507257000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/50\/5\/1006\/7944251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,1,7]]},"published-print":{"date-parts":[[2025,4,24]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llae555","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"type":"print","value":"0307-6938"},{"type":"electronic","value":"1365-2230"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,1,7]]}}}