{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:23:29Z","timestamp":1776270209223,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Line-field confocal optical coherence tomography (LC-OCT) is a new noninvasive imaging technique that provides high-resolution skin imaging similar to that obtained with histopathology. The aim of this study was to evaluate the usefulness of LC-OCT in the diagnosis of herpesvirus skin infections. Patients with a clinical or anamnestic suspicion of herpesvirus infection underwent LC-OCT evaluation followed by Tzanck test. The examinations were performed in a blinded manner by different dermatologists. In total, 72 patients (38 male, 34 female; age range 13\u201384\u2005years) were evaluated. In 57 patients, LC-OCT enabled the recognition of typical herpetic intraepidermal vesicles containing giant ballooning\/multinucleated cells, as confirmed by Tzanck test. The final diagnoses were herpes zoster in 31 patients, herpes simplex in 16 patients, varicella in 8 patients and Kaposi varicelliform eruption in 2 patients. In the remaining 15 patients, both LC-OCT and Tzanck test results excluded a diagnosis of herpetic infection. Although the diagnosis of herpesvirus skin infection is generally clinical, in patients with minimal and\/or atypical cases, LC-OCT could be a rapid and valid alternative to semi-invasive\/invasive or time-consuming procedures, such as the Tzanck test, viral culture, polymerase chain reaction or histopathology.<\/jats:p>","DOI":"10.1093\/ced\/llaf061","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T12:16:53Z","timestamp":1738585013000},"page":"1403-1405","source":"Crossref","is-referenced-by-count":2,"title":["A novel technique for noninvasive diagnosis of\u00a0herpesvirus-related skin conditions"],"prefix":"10.1093","volume":"50","author":[{"given":"Anna Elisa","family":"Verz\u00ec","sequence":"first","affiliation":[{"name":"Dermatology Clinic, University of Catania ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Lacarrubba","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, University of Catania ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Dimarco","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, University of Catania ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Micali","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, University of Catania ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"2025062505023891400_llaf061-B1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cnur.2020.05.004","article-title":"Herpes simplex virus: epidemiology, diagnosis, and treatment","volume":"55","author":"Cole","year":"2020","journal-title":"Nurs Clin North 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