{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:01:50Z","timestamp":1778605310272,"version":"3.51.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100010905","name":"major research plan","doi-asserted-by":"publisher","award":["2024SF-YBXM-295"],"award-info":[{"award-number":["2024SF-YBXM-295"]}],"id":[{"id":"10.13039\/501100010905","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Psoriasis is a common autoimmune inflammatory disease. Vitamin B6 is crucial for the body\u2019s inflammatory response, yet the relationship between 4-pyridoxic acid (4-PA), pyridoxal 5\u2032-phosphate (PLP) and vitamin B6 turnover (4-PA\/PLP) in psoriasis remains unexplored.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate the relationship of 4-PA, PLP and vitamin B6 catabolism with the risk of psoriasis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This cross-sectional study analysed records for 7540 participants from the US National Health and Nutrition Examination Survey. Vitamin B6 catabolism was assessed via the serum 4-PA to PLP ratio (4-PA\/PLP). The primary outcome was psoriasis, evaluated using weighted univariate and multivariate logistic regression to determine odds ratios (OR) and 95% confidence intervals (CI). Subgroup analyses were performed by age, gender, body mass index (BMI), hypertension, dyslipidaemia and cardiovascular disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the participants, 208 had psoriasis. After adjusting for confounders, 4-PA levels in the \u2018cutoff above\u2019 group were positively associated with psoriasis (OR 1.51, 95% CI 1.03\u20132.20). Additionally, 4-PA\/PLP correlated with an increased psoriasis risk (OR 1.82, 95% CI 1.02\u20133.26). However, PLP levels did not show a significant association. The positive link between 4-PA\/PLP and psoriasis was consistent in individuals with BMI \u2265 25\u2005kg m\u2013\u00b2 and hypertension, and in those without dyslipidaemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The results revealed a significant association between 4-PA and 4-PA\/PLP levels in the presence of psoriasis. However, further extensive prospective studies are necessary to establish causality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llaf065","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T21:03:06Z","timestamp":1739394186000},"page":"1366-1372","source":"Crossref","is-referenced-by-count":4,"title":["Vitamin B6 catabolism and psoriasis risk: a cross-sectional study"],"prefix":"10.1093","volume":"50","author":[{"given":"Ruimin","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Dermatology, First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics, Xi\u2019an Jiaotong University , Xi\u2019an ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Dermatology, First Affiliated Hospital of Xi\u2019an Jiaotong University , Xi\u2019an 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