{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:13:31Z","timestamp":1767849211599,"version":"3.49.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Acanthosis nigricans (AN) is a prevalent dermatological issue with numerous treatment options that are not entirely satisfactory. Topical vitamin D analogues have been found to be effective and safe for treating AN; however, other preparations of vitamin D have not, to the best of our knowledge, been studied yet.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the safety and efficacy of intralesional vitamin D3 injection in treating pseudo-AN.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We enrolled 30 participants who had bilateral pseudo-AN of the neck. Every patient received intralesional vitamin D3 therapy on the right side of the neck and intralesional saline as a control on the left side over the course of four sessions, each spaced 1 week apart. Participants were assessed clinically 1\u2005month after the last treatment session using the Acanthosis Nigricans Area and Severity Index (ANASI) score in addition to dermoscopic examination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A statistically significant difference in the ANASI score was seen between the treated and control sides after treatment, with the intralesional vitamin D-treated side exhibiting a larger percentage of reduction than the control side. Intralesional vitamin D3 treatment significantly improved dermoscopic features such as cristae cutis, sulci cutis and pigmented dots compared with the placebo treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Intralesional vitamin D3 is a safe and effective modality for treating pseudo-AN.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llaf067","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T20:21:32Z","timestamp":1738700492000},"page":"1330-1336","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the efficacy and safety of intralesional vitamin D3 injection in the treatment of acanthosis nigricans: a split-neck comparative study"],"prefix":"10.1093","volume":"50","author":[{"given":"Mona S","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine for Girls, Al-Azhar University , Cairo ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hala M","family":"El-Sadek","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine for Girls, Al-Azhar University , Cairo ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6212-9748","authenticated-orcid":false,"given":"Mahmoud A","family":"Rageh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Al-Azhar University , Cairo ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"2025062505023154600_llaf067-B1","doi-asserted-by":"crossref","first-page":"e13428","DOI":"10.1111\/srt.13428","article-title":"Correlation between Acanthosis Nigricans Scoring Chart (ANSC) and narrowband reflectance spectrophotometer in assessing severity of acanthosis nigricans","volume":"29","author":"Treesirichod","year":"2023","journal-title":"Skin Res Technol"},{"key":"2025062505023154600_llaf067-B2","first-page":"4133","article-title":"Acanthosis nigricans: to be or not to be afraid","volume":"17","author":"Popa","year":"2019","journal-title":"Oncol Lett"},{"key":"2025062505023154600_llaf067-B3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2174\/1573396318666220429085231","article-title":"Acanthosis nigricans: an updated review","volume":"19","author":"Leung","year":"2022","journal-title":"Curr Pediatr Rev"},{"key":"2025062505023154600_llaf067-B4","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1365-4362.1976.tb04895.x","article-title":"Classification of acanthosis nigricans","volume":"15","author":"Curth","year":"1976","journal-title":"Int J Dermatol"},{"key":"2025062505023154600_llaf067-B5","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1365-4362.1984.tb05698.x","article-title":"On the classification of Acanthosis Nigricans","volume":"23","author":"Hern\u00e1ndez-P\u00e9rez","year":"1984","journal-title":"Int J Dermatol"},{"key":"2025062505023154600_llaf067-B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0190-9622(94)70128-8","article-title":"Acanthosis nigricans","volume":"31","author":"Schwartz","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"2025062505023154600_llaf067-B7","first-page":"36","article-title":"Fractional carbon dioxide laser versus trichloroacetic acid 20% peel in the treatment of acanthosis nigricans: a split neck comparative study","volume":"16","author":"Fouda","year":"2023","journal-title":"J Clin Aesthet 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study","volume":"21","author":"Zeeshan","year":"2022","journal-title":"J Cosmet Dermatol"},{"key":"2025062505023154600_llaf067-B11","first-page":"884","article-title":"Comparison of metformin versus rosiglitazone in patients with acanthosis nigricans: a pilot study","volume":"5","author":"Bellot-Rojas","year":"2006","journal-title":"J Drugs Dermatol"},{"key":"2025062505023154600_llaf067-B12","first-page":"1158","article-title":"Treatment of acanthosis nigricans of the axillae using a long-pulsed (5-msec) alexandrite laser","volume":"30","author":"Rosenbach","year":"2004","journal-title":"Dermatol Surg"},{"key":"2025062505023154600_llaf067-B13","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s10103-019-02944-9","article-title":"Comparison of the effectiveness of fractional 1550-nm erbium fiber laser and 0.05% tretinoin cream in the treatment of acanthosis nigricans: a prospective, randomized, controlled 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A critically appraised topic","volume":"170","author":"Kassim","year":"2014","journal-title":"Br J Dermatol"},{"key":"2025062505023154600_llaf067-B24","doi-asserted-by":"crossref","first-page":"1095181","DOI":"10.3389\/fddev.2023.1095181","article-title":"Molecular distribution in intradermal injection for transfer and delivery of therapeutics","volume":"3","author":"Lallow","year":"2023","journal-title":"Front Drug Deliv"},{"key":"2025062505023154600_llaf067-B25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11154-011-9194-0","article-title":"Vitamin D and the skin: physiology and pathophysiology","volume":"13","author":"Bikle","year":"2012","journal-title":"Rev Endocr Metab Disord"},{"key":"2025062505023154600_llaf067-B26","first-page":"1107","article-title":"Acanthosis nigricans, vitamin D, and insulin resistance in obese children and adolescents","volume":"27","author":"Slyper","year":"2014","journal-title":"J Pediatr Endocrinol Metab"},{"key":"2025062505023154600_llaf067-B27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4103\/jewd.jewd_41_22","article-title":"Assessment of serum levels of vitamin D and tissue levels of vitamin D receptors in acanthosis nigricans","volume":"20","author":"Tahlawy S","year":"2023","journal-title":"J Egypt Women\u2019s Dermatol Soc"},{"key":"2025062505023154600_llaf067-B28","first-page":"235","article-title":"Relationship between Vitamin D level and metabolic parameters in obese children and response to Vitamin D treatment","volume":"9","author":"Saymazlar","year":"2022","journal-title":"North Clin Istanb"},{"key":"2025062505023154600_llaf067-B29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.7812\/TPP\/14-016","article-title":"Prevalence of hypovitaminosis D and its association with comorbidities of childhood obesity","volume":"18","author":"Williams","year":"2014","journal-title":"Perm J"},{"key":"2025062505023154600_llaf067-B30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1758-5996-6-77","article-title":"Acanthosis nigricans in type 2 diabetes: prevalence, correlates and potential as a simple clinical screening tool \u2013 a cross-sectional study in the Caribbean","volume":"6","author":"Bahadursingh","year":"2014","journal-title":"Diabetol Metab Syndr"},{"key":"2025062505023154600_llaf067-B31","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1111\/jocd.16224","article-title":"Comparison of efficacy and safety of tretinoin 0.05% and glycolic acid peeling 70% in axillary and neck lesions of acanthosis nigricans: a single-blinded, randomized trial","volume":"23","author":"Ghiasi","year":"2024","journal-title":"J Cosmet Dermatol"},{"key":"2025062505023154600_llaf067-B32","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1111\/jocd.14844","article-title":"Intralesional vitamin D3 in treatment of alopecia areata: a randomized controlled clinical trial","volume":"21","author":"Rashad","year":"2022","journal-title":"J Cosmet Dermatol"},{"key":"2025062505023154600_llaf067-B33","doi-asserted-by":"crossref","first-page":"e13034","DOI":"10.1111\/dth.13034","article-title":"Intralesional vitamin D3 versus intralesional purified protein derivative in treatment of multiple warts: a comparative clinical and immunological study","volume":"32","author":"Abou-Taleb","year":"2019","journal-title":"Dermatol Ther"},{"key":"2025062505023154600_llaf067-B34","first-page":"273","article-title":"Acanthosis nigricans: an extensive review","volume":"31","author":"Salati","year":"2021","journal-title":"J Pak Assoc Dermatol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llaf067\/61770747\/llaf067.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/7\/1330\/61770747\/llaf067.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/7\/1330\/61770747\/llaf067.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T09:02:45Z","timestamp":1750842165000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/50\/7\/1330\/8002768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,2,5]]},"published-print":{"date-parts":[[2025,6,25]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llaf067","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,2,5]]}}}