{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:33:38Z","timestamp":1781310818993,"version":"3.54.1"},"reference-count":118,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Primary localized cutaneous amyloidosis (PLCA) is a skin-limited disorder characterized histologically by amyloid deposition in the papillary dermis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To review current treatment strategies and provide an updated perspective on the treatment of PLCA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We searched the PubMed, EMBASE and Cochrane Library databases for eligible studies. Studies were divided into those that described nodular amyloidosis (NA) and those that described non-NA. Cohort studies were meta-analysed using a random effects model to evaluate the outcomes of different treatments, while case reports and case series were evaluated using the Mann\u2013Whitney U-test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 116 studies involving 534 patients were included. Surgery was the most effective treatment option in patients with NA, with statistically significantly better outcomes compared with other treatments. For the non-NA group, 62 case-level studies (79 patients) and 20 cohort studies (418 patients) were analysed separately. Although there were no statistically significant differences between treatments in the case-level studies, biologic agents and Janus kinase (JAK) inhibitors may be promising treatments for refractory lesions. Among the cohort studies, partial response rates of 100.0%, 100.0%, 97.5%, 96.9% and 94.4% were achieved for transcutaneous electrical nerve stimulation, microneedling, laser therapies, topical therapies and systemic immunosuppressants, respectively; complete response rates of 22.2% and 2.5% were achieved for surgical interventions and laser therapies, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study suggests that surgery is the most effective treatment option for NA, and laser therapy is recommended for patients with non-NA. Biologic agents and JAK inhibitors may be promising treatment options for lesions that do not respond to conventional therapies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llaf081","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T04:19:14Z","timestamp":1739506754000},"page":"1343-1354","source":"Crossref","is-referenced-by-count":7,"title":["Systematic review and meta-analysis of treatments and outcomes in primary localized cutaneous amyloidosis"],"prefix":"10.1093","volume":"50","author":[{"given":"Qin-Xiao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Yi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Yu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1098-7542","authenticated-orcid":false,"given":"Sheng","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"2025062505024690200_llaf081-B1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/0019-5154.147868","article-title":"Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations","volume":"60","author":"Suranagi","year":"2015","journal-title":"Indian J Dermatol"},{"key":"2025062505024690200_llaf081-B2","doi-asserted-by":"crossref","first-page":"e15213","DOI":"10.1111\/dth.15213","article-title":"Comparison of the efficacy and safety of intralesional injection of tranexamic acid and the topical application of Kligman combination drug in the treatment of macular amyloidosis","volume":"35","author":"Ghassemi","year":"2022","journal-title":"Dermatol Ther"},{"key":"2025062505024690200_llaf081-B3","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12247672","article-title":"Primary localized cutaneous amyloidosis in Central Europe: a retrospective monocentric study on epidemiology and therapy","volume":"12","author":"P\u00e1lla","year":"2023","journal-title":"J Clin Med"},{"key":"2025062505024690200_llaf081-B4","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/DAD.0000000000001470","article-title":"Cutaneous nodular amyloidosis: a disfiguring aspect of the face","volume":"41","author":"Dupont","year":"2019","journal-title":"Am J Dermatopathol"},{"key":"2025062505024690200_llaf081-B5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1346-8138.2011.01247.x","article-title":"Primary localized cutaneous nodular amyloidosis that appeared in a patient with severe atopic dermatitis","volume":"39","author":"Fujisawa","year":"2012","journal-title":"J Dermatol"},{"key":"2025062505024690200_llaf081-B6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1365-4362.1986.tb02224.x","article-title":"Failure of etretinate (RO 10-9359) in lichen amyloidosus","volume":"25","author":"Aram","year":"1986","journal-title":"Int J Dermatol"},{"key":"2025062505024690200_llaf081-B7","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1365-2230.1986.tb00511.x","article-title":"Treatment of lichen amyloidosus by etretinate","volume":"11","author":"Helander","year":"1986","journal-title":"Clin Exp Dermatol"},{"key":"2025062505024690200_llaf081-B8","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0190-9622(86)70132-1","article-title":"Nodular primary localized cutaneous amyloidosis: immunohistochemical evaluation and treatment with the carbon dioxide laser","volume":"14","author":"Truhan","year":"1986","journal-title":"J Am Acad Dermatol"},{"key":"2025062505024690200_llaf081-B9","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000248840","article-title":"Effect of etretinate on lichen amyloidosus","volume":"175","author":"David","year":"1987","journal-title":"Dermatologica"},{"key":"2025062505024690200_llaf081-B10","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1001\/archderm.1988.01670050015008","article-title":"Etretinate for the treatment of lichen amyloidosis","volume":"124","author":"Marschalko","year":"1988","journal-title":"Arch Dermatol"},{"key":"2025062505024690200_llaf081-B11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1365-2230.1994.tb01148.x","article-title":"Primary nodular cutaneous amyloidosis \u2013 long-term follow-up and treatment","volume":"19","author":"Vestey","year":"1994","journal-title":"Clin Exp Dermatol"},{"key":"2025062505024690200_llaf081-B12","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1346-8138.1995.tb03915.x","article-title":"Extensive lichen amyloidosus refractory to DMSO","volume":"22","author":"Kobayashi","year":"1995","journal-title":"J Dermatol"},{"key":"2025062505024690200_llaf081-B13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/j.1346-8138.1995.tb03916.x","article-title":"Localized cutaneous amyloidosis simulating lichen simplex chronicus","volume":"22","author":"Muramatsu","year":"1995","journal-title":"J Dermatol"},{"key":"2025062505024690200_llaf081-B14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-2230.1996.tb00106.x","article-title":"Cutaneous macular amyloidosis associated with multiple endocrine neoplasia 2A","volume":"21","author":"de Argila","year":"1996","journal-title":"Clin Exp Dermatol"},{"key":"2025062505024690200_llaf081-B15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0190-9622(97)80406-9","article-title":"The efficacy of dermabrasion in the treatment of nodular amyloidosis","volume":"36","author":"Lien","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"2025062505024690200_llaf081-B16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1046\/j.1365-2230.1997.1770598.x","article-title":"Nylon cloth macular amyloidosis","volume":"22","author":"Macsween","year":"1997","journal-title":"Clin Exp Dermatol"},{"key":"2025062505024690200_llaf081-B17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1159\/000246146","article-title":"Remission of lichen amyloidosus after treatment with acitretin","volume":"194","author":"Reider","year":"1997","journal-title":"Dermatology"},{"key":"2025062505024690200_llaf081-B18","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1159\/000245965","article-title":"Lichen amyloidosus universalis associated with long-term drug intake","volume":"195","author":"Soler-Carrillo","year":"1997","journal-title":"Dermatology"},{"key":"2025062505024690200_llaf081-B19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1524-4725.1998.tb04144.x","article-title":"The treatment of lichen amyloidosis. A review and a new technique","volume":"24","author":"Harahap","year":"1998","journal-title":"Dermatol Surg"},{"key":"2025062505024690200_llaf081-B20","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1046\/j.1365-4362.1998.00600.x","article-title":"Intermittent use of topical dimethyl sulfoxide in macular and papular amyloidosis","volume":"37","author":"Ozkaya-Bayazit","year":"1998","journal-title":"Int J Dermatol"},{"key":"2025062505024690200_llaf081-B21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1524-4725.1999.08097.x","article-title":"Nodular amyloidosis treated with a pulsed dye laser","volume":"25","author":"Alster","year":"1999","journal-title":"Dermatol Surg"},{"key":"2025062505024690200_llaf081-B22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.1365-4362.1999.00714.x","article-title":"Calcipotriol ointment vs. betamethasone 17-valerate ointment in the treatment of lichen amyloidosis","volume":"38","author":"Khoo","year":"1999","journal-title":"Int J Dermatol"},{"key":"2025062505024690200_llaf081-B23","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1046\/j.1365-4362.2000.00047-4.x","article-title":"Primary localized cutaneous amyloidosis associated with autoimmune cholangitis","volume":"39","author":"Fujiwara","year":"2000","journal-title":"Int J Dermatol"},{"key":"2025062505024690200_llaf081-B24","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1046\/j.1524-4725.2000.026010958.x","article-title":"Treatment of lichen amyloidosis (LA) and disseminated superficial porokeratosis (DSP) with frequency-doubled Q-switched Nd:YAG laser","volume":"26","author":"Liu","year":"2000","journal-title":"Dermatol Surg"},{"key":"2025062505024690200_llaf081-B25","first-page":"553","article-title":"Lichen amyloidosis associated with atopic dermatitis: clinical resolution with cyclosporine","volume":"137","author":"Behr","year":"2001","journal-title":"Arch Dermatol"},{"key":"2025062505024690200_llaf081-B26","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1046\/j.1365-2230.2001.00808.x","article-title":"Widespread biphasic amyloidosis: response to acitretin","volume":"26","author":"Hernandez-Nunez","year":"2001","journal-title":"Clin Exp Dermatol"},{"key":"2025062505024690200_llaf081-B27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/120347540100500201","article-title":"Nodular amyloidosis: case report and literature review","volume":"5","author":"Kakani","year":"2001","journal-title":"J Cutan Med Surg"},{"key":"2025062505024690200_llaf081-B28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1034\/j.1600-0781.2001.170404.x","article-title":"A retrospective review of PUVA therapy at the National Skin Centre of Singapore","volume":"17","author":"Tran","year":"2001","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"2025062505024690200_llaf081-B29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/09546630252775180","article-title":"Lack of effect of dimethylsulphoxide in cutaneous amyloidosis","volume":"13","author":"Pandhi","year":"2002","journal-title":"J Dermatolog Treat"},{"key":"2025062505024690200_llaf081-B30","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1177\/120347540200600404","article-title":"Primary localized cutaneous amyloidosis in association with papillary thyroid carcinoma","volume":"6","author":"Sangen","year":"2002","journal-title":"J Cutan Med Surg"},{"key":"2025062505024690200_llaf081-B31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000051831","article-title":"Lichen amyloidosus associated with Kimura\u2019s disease: successful treatment with cyclosporine","volume":"204","author":"Teraki","year":"2002","journal-title":"Dermatology"},{"key":"2025062505024690200_llaf081-B32","first-page":"163","article-title":"Treatment of primary localised cutaneous amyloidosis with cyclophosphamide","volume":"69","author":"Das","year":"2003","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2025062505024690200_llaf081-B33","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1468-3083.2004.00940.x","article-title":"Lichen amyloidosus treated by hydrocolloid dressings","volume":"18","author":"Hallel-Halevy","year":"2004","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025062505024690200_llaf081-B34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s00266-004-3104-8","article-title":"Amyloidosis complicating rhinophyma","volume":"28","author":"Nanda","year":"2004","journal-title":"Aesthetic Plast Surg"},{"key":"2025062505024690200_llaf081-B35","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/j.1365-4632.2004.02273.x","article-title":"Thermosensitive lichen amyloidosis","volume":"43","author":"Parsi","year":"2004","journal-title":"Int J Dermatol"},{"key":"2025062505024690200_llaf081-B36","first-page":"113","article-title":"Primary localised deep cutaneous amyloidosis of the eyelid","volume":"27","author":"Mun","year":"2005","journal-title":"Malays J Pathol"},{"key":"2025062505024690200_llaf081-B37","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1468-3083.2005.01038.x","article-title":"A case of lichen amyloidosis treated with pulsed dye laser","volume":"19","author":"Sawamura","year":"2005","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025062505024690200_llaf081-B38","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1346-8138.2005.tb00728.x","article-title":"Primary localized cutaneous nodular amyloidosis in a patient with Sj\u00f6gren\u2019s syndrome: a review of the literature","volume":"32","author":"Yoneyama","year":"2005","journal-title":"J Dermatol"},{"key":"2025062505024690200_llaf081-B39","first-page":"315","article-title":"Excision and split thickness skin grafting in the treatment of nodular primary localized cutaneous amyloidosis","volume":"16","author":"Bozikov","year":"2006","journal-title":"Eur J Dermatol"},{"key":"2025062505024690200_llaf081-B40","first-page":"39","article-title":"Successful treatment of lichen amyloidosis with combined bath PUVA photochemotherapy and oral acitretin","volume":"32","author":"Grimmer","year":"2007","journal-title":"Clin Exp Dermatol"},{"key":"2025062505024690200_llaf081-B41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/09546630701271799","article-title":"Dexamethasone cyclophosphamide pulse therapy in lichen amyloidosus: a case report","volume":"18","author":"Gupta","year":"2007","journal-title":"J Dermatolog Treat"},{"key":"2025062505024690200_llaf081-B42","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2230.2007.02653.x","article-title":"A case of lichen amyloidosus accompanied by vesicles and dyschromia","volume":"33","author":"Cho","year":"2008","journal-title":"Clin Exp Dermatol"},{"key":"2025062505024690200_llaf081-B43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1440-0960.2008.00434.x","article-title":"Acitretin for lichen amyloidosus","volume":"49","author":"Choi","year":"2008","journal-title":"Australas J Dermatol"},{"key":"2025062505024690200_llaf081-B44","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1468-3083.2007.02473.x","article-title":"532-nm and 1064-nm Q-switched Nd:YAG laser therapy for reduction of pigmentation in macular amyloidosis patches","volume":"22","author":"Ostovari","year":"2008","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025062505024690200_llaf081-B45","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1346-8138.2009.00603.x","article-title":"Lichen amyloidosis of the auricular concha: successful treatment with electrodesiccation","volume":"36","author":"Aoki","year":"2009","journal-title":"J Dermatol"},{"key":"2025062505024690200_llaf081-B46","doi-asserted-by":"crossref","first-page":"524","DOI":"10.2340\/00015555-0725","article-title":"Successful treatment of therapy-resistant pruritus in lichen amyloidosis with menthol","volume":"89","author":"Frolich","year":"2009","journal-title":"Acta Derm Venereol"},{"key":"2025062505024690200_llaf081-B47","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3109\/09546630802691325","article-title":"A case of atopic dermatitis-associated lichen amyloidosis successfully treated with oral cyclosporine and narrow band UVB therapy in succession","volume":"20","author":"Kang","year":"2009","journal-title":"J Dermatolog Treat"},{"key":"2025062505024690200_llaf081-B48","doi-asserted-by":"crossref","first-page":"e833","DOI":"10.1111\/j.1365-2230.2009.03574.x","article-title":"Successful treatment of lichen amyloidosus associated with atopic dermatitis using a combination of narrowband ultraviolet B phototherapy, topical corticosteroids and an antihistamine","volume":"34","author":"Oiso","year":"2009","journal-title":"Clin Exp Dermatol"},{"key":"2025062505024690200_llaf081-B49","first-page":"129","article-title":"Clinical pattern of primary cutaneous amyloidosis in Hong Kong Chinese","volume":"17","author":"Wong","year":"2009","journal-title":"HK J Dermatol Venereol"},{"key":"2025062505024690200_llaf081-B50","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1346-8138.2008.00586.x","article-title":"Lichen amyloidosis induced on the upper back by long-term friction with a nylon towel","volume":"36","author":"Yoshida","year":"2009","journal-title":"J Dermatol"},{"key":"2025062505024690200_llaf081-B51","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1365-4632.2009.04259.x","article-title":"A rare co-occurrence of primary localized cutaneous amyloidosis and chronic C type hepatitis","volume":"49","author":"Abe","year":"2010","journal-title":"Int J Dermatol"},{"key":"2025062505024690200_llaf081-B52","first-page":"575","article-title":"Primary amyloidosis of the eyelid: a case report","volume":"24","author":"Caggiati","year":"2010","journal-title":"In Vivo"},{"key":"2025062505024690200_llaf081-B53","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1365-4632.2010.04524.x","article-title":"Nodular localized primary cutaneous amyloidosis and primary marginal zone B-cell lymphoma on the nose: treatment with microscopically controlled surgery","volume":"50","author":"Kendler","year":"2011","journal-title":"Int J Dermatol"},{"key":"2025062505024690200_llaf081-B54","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1346-8138.2010.00962.x","article-title":"Clinical effect of tocoretinate on lichen and macular amyloidosis","volume":"38","author":"Terao","year":"2011","journal-title":"J Dermatol"},{"key":"2025062505024690200_llaf081-B55","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5070\/D33QN2Q2WS","article-title":"Nodular amyloidosis in a patient with liver cirrhosis","volume":"17","author":"Ueno","year":"2011","journal-title":"Dermatol Online J"},{"key":"2025062505024690200_llaf081-B56","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1346-8138.2010.01081.x","article-title":"Transcutaneous electrical nerve stimulation for reduction of pruritus in macular amyloidosis and lichen simplex","volume":"38","author":"Y\u00fcksek","year":"2011","journal-title":"J Dermatol"},{"key":"2025062505024690200_llaf081-B57","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4103\/0974-2077.99459","article-title":"Lichen amyloidosis: novel treatment with fractional ablative 2,940\u2005nm erbium: YAG laser treatment","volume":"5","author":"Anitha","year":"2012","journal-title":"J Cutan Aesthet Surg"},{"key":"2025062505024690200_llaf081-B58","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2340\/00015555-1240","article-title":"Localized AL amyloidosis in a patient with diffuse large B-cell lymphoma of the breast","volume":"92","author":"Chiu","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"2025062505024690200_llaf081-B59","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/120347541201600519","article-title":"Effective treatment of nodular amyloidosis with carbon dioxide laser","volume":"16","author":"Lesiak","year":"2012","journal-title":"J Cutan Med Surg"},{"key":"2025062505024690200_llaf081-B60","first-page":"527","article-title":"Satisfactory response to narrowband UV-B therapy in generalized lichen amyloidosis","volume":"104","author":"Alonso-Gonzalez","year":"2013","journal-title":"Actas Dermosifiliogr"},{"key":"2025062505024690200_llaf081-B61","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1111\/j.1440-0960.2011.00770.x","article-title":"Primary localized cutaneous nodular amyloidosis successfully treated with cyclophosphamide","volume":"54","author":"Tong","year":"2013","journal-title":"Australas J Dermatol"},{"key":"2025062505024690200_llaf081-B62","first-page":"189","article-title":"Pulsed dye laser for the treatment of macular amyloidosis: a case report","volume":"93","author":"Barsky","year":"2014","journal-title":"Cutis"},{"key":"2025062505024690200_llaf081-B63","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s11255-014-0756-4","article-title":"Localised amyloidosis of the glans penis presenting as a painless lump with progression after 10\u2005years","volume":"46","author":"Floyd","year":"2014","journal-title":"Int Urol Nephrol"},{"key":"2025062505024690200_llaf081-B64","first-page":"579","article-title":"An alternative treatment model: the combination therapy of narrow band ultraviolet B phototherapy and tacrolimus ointment 0.1% in biphasic amyloidosis","volume":"64","author":"Kalkan","year":"2014","journal-title":"J Pak Med Assoc"},{"key":"2025062505024690200_llaf081-B65","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4103\/0019-5154.131430","article-title":"Nodular primary localized cutaneous amyloidosis in a patient with pulmonary sarcoidosis","volume":"59","author":"Nakai","year":"2014","journal-title":"Indian J Dermatol"},{"key":"2025062505024690200_llaf081-B66","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/dth.12057","article-title":"Successful treatment of lichen amyloidosis using a CO2 surgical laser","volume":"27","author":"Norisugi","year":"2014","journal-title":"Dermatol Ther"},{"key":"2025062505024690200_llaf081-B67","first-page":"89","article-title":"Primary localized cutaneous nodular amyloidosis of the feet: a case report and review of the literature","volume":"93","author":"Ritchie","year":"2014","journal-title":"Cutis"},{"key":"2025062505024690200_llaf081-B68","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/dth.12023","article-title":"Itch in familial lichen amyloidosis: effective treatment with amitriptyline in two cases","volume":"27","author":"Yew","year":"2014","journal-title":"Dermatol Ther"},{"key":"2025062505024690200_llaf081-B69","doi-asserted-by":"crossref","first-page":"555","DOI":"10.5603\/EP.2015.0068","article-title":"Macular amyloidosis complicating macroprolactinoma\u2013a novel clinical association","volume":"66","author":"Dutta","year":"2015","journal-title":"Endokrynol Pol"},{"key":"2025062505024690200_llaf081-B70","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/lsm.22361","article-title":"Efficacy of different modes of fractional CO2 laser in the treatment of primary cutaneous amyloidosis: a randomized clinical trial","volume":"47","author":"Esmat","year":"2015","journal-title":"Lasers Surg Med"},{"key":"2025062505024690200_llaf081-B71","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/lsm.22338","article-title":"Fractional 1,550\u2005nm Ytterbium\/Erbium fiber laser in the treatment of lichen amyloidosis: clinical and histological study","volume":"47","author":"Panchaprateep","year":"2015","journal-title":"Lasers Surg Med"},{"key":"2025062505024690200_llaf081-B72","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jpra.2015.07.006","article-title":"Treatment of rare nodular amyloidosis on the nose: a case report","volume":"6","author":"Schipper","year":"2015","journal-title":"JPRAS Open"},{"key":"2025062505024690200_llaf081-B73","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/ijd.12140","article-title":"Nodular localized cutaneous amyloidosis in an immunosuppressed patient","volume":"54","author":"Yong","year":"2015","journal-title":"Int J Dermatol"},{"key":"2025062505024690200_llaf081-B74","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/ajd.12316","article-title":"Oral isotretinoin: a new treatment alternative for generalized lichen amyloidosis","volume":"57","author":"Atacan","year":"2016","journal-title":"Australas J Dermatol"},{"key":"2025062505024690200_llaf081-B75","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000443950","article-title":"Nodular cutaneous amyloidosis resembling a giant tumor","volume":"8","author":"Haverkampf","year":"2016","journal-title":"Case Rep Dermatol"},{"key":"2025062505024690200_llaf081-B76","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1590\/abd1806-4841.20164316","article-title":"Primary localized cutaneous amyloidosis with lichen and poikiloderma-like lesions and an excellent response to systemic acitretin","volume":"91","author":"Ma","year":"2016","journal-title":"An Bras Dermatol"},{"key":"2025062505024690200_llaf081-B77","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jdcr.2016.04.006","article-title":"Nodular cutaneous amyloidosis effectively treated with intralesional methotrexate","volume":"2","author":"Raymond","year":"2016","journal-title":"JAAD Case Reports"},{"key":"2025062505024690200_llaf081-B78","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000447234","article-title":"Nodular cutaneous amyloidosis at the temple","volume":"8","author":"Schucht","year":"2016","journal-title":"Case Rep Dermatol"},{"key":"2025062505024690200_llaf081-B79","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/jdv.13048","article-title":"Successful treatment of lichen amyloidosus with oral alitretinoin","volume":"30","author":"Tietze","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025062505024690200_llaf081-B80","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/jdv.13165","article-title":"Successful treatment of lichen amyloidosis using capsaicin 8% patch","volume":"30","author":"Zeidler","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025062505024690200_llaf081-B81","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijwd.2016.11.003","article-title":"Three cases of localized cutaneous nodular amyloidosis in patients with limited systemic sclerosis and a brief literature review","volume":"3","author":"Goettsche","year":"2017","journal-title":"Int J Womens Dermatol"},{"key":"2025062505024690200_llaf081-B82","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12537","article-title":"Alitretinoin treatment of lichen amyloidosis","volume":"30","author":"Koh","year":"2017","journal-title":"Dermatol Ther"},{"key":"2025062505024690200_llaf081-B83","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.sjopt.2017.05.005","article-title":"A case of localized amyloidosis of the eyelid misdiagnosed as recurrent chalazion","volume":"31","author":"Manaa Alkatan","year":"2017","journal-title":"Saudi J Ophthalmol"},{"key":"2025062505024690200_llaf081-B84","first-page":"240","article-title":"Nodular primary localized cutaneous amyloidosis in a 54-year-old man","volume-title":"Dermatol Sin","author":"Chen","year":"2018"},{"key":"2025062505024690200_llaf081-B85","first-page":"156","article-title":"Primary localized cutaneous nodular amyloidosis of the cheeks","volume-title":"Akt Dermatol","author":"Jievaltaite","year":"2018"},{"key":"2025062505024690200_llaf081-B86","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s10103-018-2457-1","article-title":"Comparative study of fractional CO2 laser and fractional CO2 laser-assisted drug delivery of topical steroid and topical vitamin C in macular amyloidosis","volume":"33","author":"Sobhi","year":"2018","journal-title":"Lasers Med Sci"},{"key":"2025062505024690200_llaf081-B87","doi-asserted-by":"crossref","DOI":"10.5070\/D3242038171","article-title":"An intensely pruritic pebbled presentation","volume":"24","author":"Soriano","year":"2018","journal-title":"Dermatol Online J"},{"key":"2025062505024690200_llaf081-B88","doi-asserted-by":"crossref","first-page":"900","DOI":"10.2340\/00015555-2991","article-title":"Methotrexate for the treatment of recalcitrant primary localized cutaneous amyloidosis: a case series","volume":"98","author":"Stull","year":"2018","journal-title":"Acta Derm Venereol"},{"key":"2025062505024690200_llaf081-B89","doi-asserted-by":"crossref","first-page":"e0004","DOI":"10.1097\/MD.0000000000010004","article-title":"Primary cutaneous amyloidosis associated with autoimmune hepatitis-primary biliary cirrhosis overlap syndrome and Sj\u00f6gren syndrome","volume":"97","author":"Yan","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"2025062505024690200_llaf081-B90","doi-asserted-by":"crossref","first-page":"2050313X19890755","DOI":"10.1177\/2050313X19890755","article-title":"Localized ulcerative nodular amyloidosis presenting as ulcerative panniculitis, an unusual clinical manifestation: a case report","volume":"7","author":"Fernandes","year":"2019","journal-title":"SAGE Open Med Case Rep"},{"key":"2025062505024690200_llaf081-B91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14764172.2017.1406605","article-title":"Lichen amyloidosis successfully treated with fractional ablative laser CO(2): a new alternative therapeutic","volume":"21","author":"Korbi","year":"2019","journal-title":"J Cosmet Laser Ther"},{"key":"2025062505024690200_llaf081-B92","doi-asserted-by":"crossref","DOI":"10.5070\/D32612051364","article-title":"Clinical resolution of generalized lichen amyloidosis with dupilumab: a new alternative therapy","volume":"26","author":"Humeda","year":"2020","journal-title":"Dermatol Online J"},{"key":"2025062505024690200_llaf081-B93","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s10103-020-02954-y","article-title":"A comparative study of the efficacy of fractional neodymium-doped yttrium aluminium garnet (Nd:YAG) laser therapy alone and in combination with erbium:YAG laser therapy: tracing and objective measurement of melanin index in macular amyloidosis","volume":"35","author":"Nilforoushzadeh","year":"2020","journal-title":"Lasers Med Sci"},{"key":"2025062505024690200_llaf081-B94","doi-asserted-by":"crossref","first-page":"e13305","DOI":"10.1111\/dth.13305","article-title":"Efficacy of topical dimethyl sulfoxide (DMSO) 50% solution vs tretinoin 0.5% cream in treatment of patients with primary macular amyloidosis: a split-side single-blinded randomized clinical trial","volume":"33","author":"Saki","year":"2020","journal-title":"Dermatol Ther"},{"key":"2025062505024690200_llaf081-B95","doi-asserted-by":"crossref","first-page":"e15005","DOI":"10.1111\/dth.15005","article-title":"A case of lichen amyloidosis associated with atopic dermatitis successfully treated with dupilumab: a case report and literature review","volume":"34","author":"Aoki","year":"2021","journal-title":"Dermatol Ther"},{"key":"2025062505024690200_llaf081-B96","article-title":"First case of nodular localized primary cutaneous amyloidosis treated with bortezomib and dexamethasone","volume":"9","author":"Khan","year":"2021","journal-title":"J Investig Med High Impact Case Rep"},{"key":"2025062505024690200_llaf081-B97","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1159\/000519030","article-title":"A peculiar case of large and \u201cunresectable\u201d primary localized cutaneous nodular amyloidosis of the ankle","volume":"13","author":"Stanizzi","year":"2021","journal-title":"Case Rep Dermatol"},{"key":"2025062505024690200_llaf081-B98","first-page":"e29010","article-title":"A case of perifollicular macular amyloidosis","volume":"14","author":"Baig","year":"2022","journal-title":"Cureus"},{"key":"2025062505024690200_llaf081-B99","doi-asserted-by":"crossref","first-page":"e15312","DOI":"10.1111\/dth.15312","article-title":"Tofacitinib for the treatment of primary cutaneous amyloidosis: a case report","volume":"35","author":"Chen","year":"2022","journal-title":"Dermatol Ther"},{"key":"2025062505024690200_llaf081-B100","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/ced.15016","article-title":"Role of sequential chemical peel in cutaneous amyloidosis: a pilot case series","volume":"47","author":"Divyalakshmi","year":"2022","journal-title":"Clin Exp Dermatol"},{"key":"2025062505024690200_llaf081-B101","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1159\/000518948","article-title":"Primary localized cutaneous amyloidosis: a retrospective study of an uncommon skin disease in the largest tertiary care center in Switzerland","volume":"238","author":"Guillet","year":"2022","journal-title":"Dermatology"},{"key":"2025062505024690200_llaf081-B102","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1097\/DAD.0000000000002263","article-title":"Cutaneous ossifying amyloidoma","volume":"44","author":"Requena","year":"2022","journal-title":"Am J Dermatopathol"},{"key":"2025062505024690200_llaf081-B103","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1111\/1346-8138.16378","article-title":"Primary localized cutaneous amyloidosis presenting only as hypopigmented patches: a case report","volume":"49","author":"Wang","year":"2022","journal-title":"J Dermatol"},{"key":"2025062505024690200_llaf081-B104","doi-asserted-by":"crossref","first-page":"e15724","DOI":"10.1111\/dth.15724","article-title":"Refractory cutaneous lichen amyloidosis coexisting with atopic dermatitis responds to the Janus kinase inhibitor baricitinib","volume":"35","author":"Xia","year":"2022","journal-title":"Dermatol Ther"},{"key":"2025062505024690200_llaf081-B105","doi-asserted-by":"crossref","first-page":"e1071","DOI":"10.1111\/jdv.18482","article-title":"Dramatic response to dupilumab in papular amyloidosis","volume":"36","author":"Zahid","year":"2022","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025062505024690200_llaf081-B106","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.3390\/curroncol29050246","article-title":"Cutaneous involvement in diseases with plasma cell differentiation: diagnostic approach","volume":"29","author":"Zanelli","year":"2022","journal-title":"Curr Oncol"},{"key":"2025062505024690200_llaf081-B107","first-page":"833","article-title":"Immunoglobulin G4-related disease-associated dermatitis with pruritus: a positive response to dupilumab","volume":"13","author":"Beck","year":"2023","journal-title":"Life (Basel"},{"key":"2025062505024690200_llaf081-B108","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.5021\/ad.20.137","article-title":"Primary localized cutaneous nodular amyloidosis on scalp successfully treated with excision","volume":"35","author":"Kwon","year":"2023","journal-title":"Ann Dermatol"},{"key":"2025062505024690200_llaf081-B109","first-page":"37","article-title":"Lichen amyloidosis","volume":"110","author":"Milewska","year":"2023","journal-title":"Prz Dermatol"},{"key":"2025062505024690200_llaf081-B110","doi-asserted-by":"crossref","first-page":"e633","DOI":"10.1111\/jdv.18756","article-title":"Upadacitinib for treatment-resistant lichen amyloidosis","volume":"37","author":"Solimani","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025062505024690200_llaf081-B111","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.12998\/wjcc.v11.i10.2301","article-title":"Dupilumab for treatment of severe atopic dermatitis accompanied by lichenoid amyloidosis in adults: two case reports","volume":"11","author":"Zhao","year":"2023","journal-title":"World J Clin Cases"},{"key":"2025062505024690200_llaf081-B112","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.12998\/wjcc.v11.i11.2549","article-title":"Successful treatment of lichen amyloidosis coexisting with atopic dermatitis by dupilumab: four case reports","volume":"11","author":"Zhu","year":"2023","journal-title":"World J Clin Cases"},{"key":"2025062505024690200_llaf081-B113","doi-asserted-by":"crossref","first-page":"e989-92","DOI":"10.1111\/jdv.20039","article-title":"Primary localized cutaneous amyloidosis associated with atopic dermatitis treated successfully with nemolizumab","volume":"38","author":"Fukumoto","year":"2024","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025062505024690200_llaf081-B114","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1111\/jocd.16517","article-title":"The effect of topical tranexamic acid with micro-needling and micro-needling alone in treatment of macular amyloidosis","volume":"23","author":"Gheisari","year":"2024","journal-title":"J Cosmet Dermatol"},{"key":"2025062505024690200_llaf081-B115","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bjps.2024.06.010","article-title":"Cutaneous amyloidosis mimicking basal cell carcinoma: a case series and literature review","volume":"95","author":"Lim","year":"2024","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"2025062505024690200_llaf081-B116","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s10103-023-03965-1","article-title":"Evaluation and comparison of Q-switched Nd:YAG laser 1064 nm and Er:YAG laser 2940 nm in the treatment of macular amyloidosis","volume":"39","author":"Mokhtari","year":"2024","journal-title":"Lasers Med Sci"},{"key":"2025062505024690200_llaf081-B117","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/bjd.14510","article-title":"Interleukin-31 receptor and pruritus associated with primary localized cutaneous amyloidosis","volume":"175","author":"He","year":"2016","journal-title":"Br J Dermatol"},{"key":"2025062505024690200_llaf081-B118","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/bjd.14391","article-title":"Pathophysiology of pruritus in primary localized cutaneous amyloidosis","volume":"174","author":"Tey","year":"2016","journal-title":"Br J Dermatol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llaf081\/61905669\/llaf081.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/7\/1343\/61905669\/llaf081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/7\/1343\/61905669\/llaf081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T09:03:08Z","timestamp":1750842188000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/50\/7\/1343\/8016438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,17]]},"references-count":118,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,2,17]]},"published-print":{"date-parts":[[2025,6,25]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llaf081","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,2,17]]}}}