{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:22:02Z","timestamp":1768893722785,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cutaneous warts continue to represent a therapeutic challenge because of treatment resistance and the inconvenience of most modalities of treatment. Topical methotrexate (MTX) with improved delivery methods may be a viable tool for certain localized dermatological conditions. Regarding cutaneous warts, MTX, either topical or intralesional, is one of the promising lines of treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate the efficacy and safety of topical MTX hydrogel 1% combined with microneedling in the treatment of cutaneous warts compared with traditional cryotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Sixty-eight patients with common or plantar warts were enrolled in this study. Patients were divided randomly into two groups: group A, which included 34 patients who received topical MTX hydrogel 1% combined with microneedling, and group B, which included 34 patients who received cryotherapy. All patients were followed up for 3\u2005months after finishing treatment to detect any recurrence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Regarding size after treatment, the complete resolution of warts was higher in group B (65%, 22\/34) than in group A (53%, 18\/34). The difference between both groups in clinical response did not reach statistical significance. There was no statistically significant difference between groups A and B regarding pain and erythema (P = 0.28 and P = 0.51, respectively). The rates of blistering and hypopigmentation were significantly higher in group B than in group A (P &amp;lt; 0.001 and P &amp;lt; 0.05, respectively). During the 3-month follow-up period, no recurrence was found in either group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Topical MTX hydrogel 1% combined with microneedling is an effective and safe therapeutic option in the treatment of common and plantar warts.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llaf102","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T16:24:08Z","timestamp":1741105448000},"page":"1535-1541","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of topical methotrexate gel 1% in combination with microneedling vs. cryotherapy for the treatment of cutaneous warts: a prospective randomized controlled trial"],"prefix":"10.1093","volume":"50","author":[{"given":"Eman Riad Mohamed","family":"Hofny","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Assiut University ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khulood Fadhl","family":"Alhakami","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Assiut University ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara A","family":"Abouelmagd","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Assiut University , Assiut ,","place":["Egypt"]},{"name":"Institute of Drug Development and Innovation Research, Assiut University , Assiut ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara A","family":"Hassan","sequence":"additional","affiliation":[{"name":"Institute of Drug Development and Innovation Research, Assiut University , Assiut ,","place":["Egypt"]},{"name":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Badr University in Assiut , Naser City, Assiut ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3001-8918","authenticated-orcid":false,"given":"Eman","family":"Fathy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Assiut University ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3467-3970","authenticated-orcid":false,"given":"Heba","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Assiut University ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"2025072412172201400_llaf102-B1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jcv.2013.02.021","article-title":"HPV type in plantar warts influences natural course and treatment response: secondary 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