{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:13:37Z","timestamp":1779934417288,"version":"3.53.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23AR077073"],"award-info":[{"award-number":["K23AR077073"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dermatology Foundation and Skin of Color Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,25]]},"abstract":"<jats:p>In this retrospective study, we investigated the role of baseline IgE levels in predicting the treatment response to dupilumab in patients with prurigo nodularis (PN). Our findings showed that patients with elevated IgE experienced significantly greater relief from pruritus following dupilumab treatment, suggesting that IgE could serve as a biomarker for identifying individuals who are more likely to benefit from treatments that target interleukin (IL)-4 and IL-13. These results support the development of personalized treatment strategies based on inflammatory profiles in patients with PN.<\/jats:p>","DOI":"10.1093\/ced\/llaf105","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T20:55:01Z","timestamp":1741121701000},"page":"1441-1443","source":"Crossref","is-referenced-by-count":2,"title":["Circulating IgE levels as a biomarker for treatment response to dupilumab among patients with prurigo nodularis"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9692-9306","authenticated-orcid":false,"given":"Anjali J","family":"D\u2019Amiano","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-8523","authenticated-orcid":false,"given":"Yagiz Matthew","family":"Akiska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6598-377X","authenticated-orcid":false,"given":"Jack","family":"Kollings","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2069-9985","authenticated-orcid":false,"given":"Aaron","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrinda","family":"Madan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6022-6659","authenticated-orcid":false,"given":"Emily","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani S","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3736-1515","authenticated-orcid":false,"given":"Shawn\u00a0G","family":"Kwatra","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"2025062505022522600_llaf105-B1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1093\/bjd\/ljae052","article-title":"Prurigo nodularis: new insights into pathogenesis and novel therapeutics","volume":"190","author":"Liao","year":"2024","journal-title":"Br J Dermatol"},{"key":"2025062505022522600_llaf105-B2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jaad.2019.09.007","article-title":"Analysis of real-world treatment patterns in patients with prurigo nodularis","volume":"82","author":"Huang","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"2025062505022522600_llaf105-B3","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/s41591-023-02320-9","article-title":"Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials","volume":"29","author":"Yosipovitch","year":"2023","journal-title":"Nat Med"},{"key":"2025062505022522600_llaf105-B4","doi-asserted-by":"crossref","first-page":"8098","DOI":"10.1038\/s41598-024-58013-x","article-title":"Comprehensive plasma cytokine and chemokine profiling in prurigo nodularis reveals endotypes in Type 2 inflammation","volume":"14","author":"Cornman","year":"2024","journal-title":"Sci Rep"},{"key":"2025062505022522600_llaf105-B5","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.jaad.2023.01.042","article-title":"The blood proteomic signature of prurigo nodularis reveals distinct inflammatory and neuropathic endotypes: a cluster analysis","volume":"88","author":"Parthasarathy","year":"2023","journal-title":"J Am Acad Dermatol"},{"key":"2025062505022522600_llaf105-B6","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jaad.2024.01.036","article-title":"Baseline eosinophil level may be a predictive indicator for the effectiveness of dupilumab in patients with prurigo nodularis: a single-center, real-world prospective study","volume":"90","author":"Yi","year":"2024","journal-title":"J Am Acad Dermatol"},{"key":"2025062505022522600_llaf105-B7","doi-asserted-by":"crossref","first-page":"206","DOI":"10.4168\/aair.2021.13.2.206","article-title":"Total IgE as a marker for chronic spontaneous urticaria","volume":"13","author":"Altrichter","year":"2021","journal-title":"Allergy Asthma Immunol Res"},{"key":"2025062505022522600_llaf105-B8","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/1346-8138.15843","article-title":"Dupilumab shows slow, steady effectiveness for intractable prurigo in patients with atopic dermatitis","volume":"48","author":"Takeuchi","year":"2021","journal-title":"J Dermatol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llaf105\/62178863\/llaf105.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/7\/1441\/62178863\/llaf105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/7\/1441\/62178863\/llaf105.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T09:02:37Z","timestamp":1750842157000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/50\/7\/1441\/8043283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,27]]},"references-count":8,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,2,27]]},"published-print":{"date-parts":[[2025,6,25]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llaf105","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,2,27]]}}}