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We describe a patient with difficult-to-treat atopic eczema who was started on upadacitinib and subsequently developed widespread cutaneous lesions, later confirmed on histopathology to be in keeping with ARPC. To the best of our knowledge, there have been no previous reports of ARPC secondary to upadacitinib.<\/jats:p>","DOI":"10.1093\/ced\/llaf122","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T18:59:56Z","timestamp":1741892396000},"page":"1452-1453","source":"Crossref","is-referenced-by-count":3,"title":["A unique case of reactive perforating collagenosis secondary to upadacitinib treatment of severe atopic eczema"],"prefix":"10.1093","volume":"50","author":[{"given":"Emily","family":"Morrison","sequence":"first","affiliation":[{"name":"Dermatology Department, Mersey and West Lancashire Teaching Hospitals NHS Trust , St Helens ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Enn","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mersey and West Lancashire Teaching Hospitals NHS Trust , Whiston ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok","family":"Ngan","sequence":"additional","affiliation":[{"name":"Dermatology Department, Mersey and West Lancashire Teaching Hospitals NHS Trust , St Helens ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"2025062505023813600_llaf122-B1","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/S0140-6736(21)00589-4","article-title":"Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD Up): results from a randomised, double-blind, placebo-\u00adcontrolled, phase 3 trial","volume":"397","author":"Reich","year":"2021","journal-title":"Lancet"},{"key":"2025062505023813600_llaf122-B2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0190-9622(84)80259-5","article-title":"The perforating disorders","volume":"10","author":"Patterson","year":"1984","journal-title":"J Am Acad Dermatol"},{"key":"2025062505023813600_llaf122-B3","doi-asserted-by":"crossref","first-page":"548","DOI":"10.25259\/IJDVL_288_20","article-title":"Erlotinib-induced reactive perforating collagenosis in a case of lung adenocarcinoma","volume":"87","author":"Jiang","year":"2021","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2025062505023813600_llaf122-B4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jdcr.2024.04.017","article-title":"A potential new treatment with upadacitinib for acquired reactive perforating collagenosis","volume":"48","author":"Ding","year":"2024","journal-title":"JAAD Case Rep"},{"key":"2025062505023813600_llaf122-B5","doi-asserted-by":"crossref","first-page":"1388274","DOI":"10.3389\/fimmu.2024.1388274","article-title":"Effectiveness of baricitinib in acquired reactive perforating collegenosis: a case report","volume":"15","author":"Zheng","year":"2024","journal-title":"Front Immunol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llaf122\/62402787\/llaf122.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/7\/1452\/62402787\/llaf122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/7\/1452\/62402787\/llaf122.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T09:02:43Z","timestamp":1750842163000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/50\/7\/1452\/8075112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,13]]},"references-count":5,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,3,13]]},"published-print":{"date-parts":[[2025,6,25]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llaf122","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,3,13]]}}}