{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:14:49Z","timestamp":1789391689106,"version":"build-2803163510"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100020412","name":"Humanitas Research Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Janus kinase (JAK) inhibitors are widely used for treating atopic dermatitis (AD) and alopecia areata (AA). Weight gain is an emergent adverse event associated with JAK inhibitors, particularly those acting on the JAK2 pathway. We conducted a retrospective monocentric two-cohort study, including 226 patients, to evaluate the prevalence of weight gain in patients with AD and AA who were treated with JAK inhibitors for \u2265 1\u2005year. We included 142 patients in the JAK1\/2 cohort (receiving upadacitinib 30\u2005mg or baricitinib 4\u2005mg) and 84 in the JAK1 cohort (receiving upadacitinib 15\u2005mg or abrocitinib 100\u2005mg). The JAK1\/2 cohort showed an additional weight gain throughout the study period (at week 52: \u03b2 = 1.84, 95% confidence interval 1.41\u20132.28, P &amp;lt; 0.001). In conclusion, patients receiving JAK1\/2 inhibitors for AD or AA are at a greater risk of weight gain than those treated with JAK1 inhibitors, likely because of impaired leptin signalling.<\/jats:p>","DOI":"10.1093\/ced\/llaf144","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T17:19:30Z","timestamp":1743441570000},"page":"1834-1837","source":"Crossref","is-referenced-by-count":19,"title":["Potential role of leptin in Janus kinase 2 inhibitor-associated weight gain: a monocentric retrospective study"],"prefix":"10.1093","volume":"50","author":[{"given":"Luciano","family":"Ibba","sequence":"first","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital , Rozzano, Milan ,","place":["Italy"]},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6051-1676","authenticated-orcid":false,"given":"Luigi","family":"Gargiulo","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital , Rozzano, Milan ,","place":["Italy"]},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bianco","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital , Rozzano, Milan ,","place":["Italy"]},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3780-5318","authenticated-orcid":false,"given":"Sara","family":"Di Giulio","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital , Rozzano, Milan ,","place":["Italy"]},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruggero","family":"Cascio Ingurgio","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital , Rozzano, Milan ,","place":["Italy"]},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Alfano","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital , Rozzano, Milan ,","place":["Italy"]},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo A","family":"Vignoli","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital , Rozzano, Milan ,","place":["Italy"]},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Valenti","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital , Rozzano, Milan ,","place":["Italy"]},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Facheris","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital , Rozzano, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Perugini","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital , Rozzano, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Narcisi","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital , Rozzano, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Costanzo","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital , Rozzano, Milan ,","place":["Italy"]},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"2025082212465600600_llaf144-B1","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.3390\/jcm12082865","article-title":"The use of JAK\/STAT inhibitors in chronic inflammatory disorders","volume":"12","author":"Caiazzo","year":"2023","journal-title":"J Clin Med"},{"key":"2025082212465600600_llaf144-B2","first-page":"19","article-title":"JAK-inhibitors in dermatology \u2013 small molecules, big impact? Overview of the mechanism of action, previous study results and potential adverse effects","volume":"20","author":"Klein","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"2025082212465600600_llaf144-B3","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2147\/CCID.S329442","article-title":"Practical use of upadacitinib in patients with severe atopic dermatitis in a real-world setting: a systematic review","volume":"17","author":"Ibba","year":"2024","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2025082212465600600_llaf144-B4","first-page":"393","article-title":"Characterization of on-target adverse events caused by TRK inhibitor therapy","volume":"31","author":"Liu","year":"2020","journal-title":"Ann Oncol"},{"key":"2025082212465600600_llaf144-B5","doi-asserted-by":"crossref","first-page":"45638","DOI":"10.1074\/jbc.M304165200","article-title":"Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance","volume":"278","author":"Huan","year":"2003","journal-title":"J Biol Chem"},{"key":"2025082212465600600_llaf144-B6","doi-asserted-by":"crossref","first-page":"16609","DOI":"10.1038\/s41598-019-53056-x","article-title":"Metabolic effects of JAK1\/2 inhibition in patients with myeloproliferative neoplasms","volume":"9","author":"Sapre","year":"2019","journal-title":"Sci Rep"},{"key":"2025082212465600600_llaf144-B7","first-page":"1062","article-title":"Ruxolitinib can cause weight gain by blocking leptin signaling in the brain via JAK2\/STAT3","volume":"135","author":"Moll\u00e9","year":"2020","journal-title":"Blood"},{"key":"2025082212465600600_llaf144-B8","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1136\/annrheumdis-2020-219012","article-title":"JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib","volume":"80","author":"Traves","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"2025082212465600600_llaf144-B9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s13075-019-1964-1","article-title":"Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations","volume":"21","author":"McInnes","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"2025082212465600600_llaf144-B10","first-page":"1293","article-title":"The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure","volume":"82","author":"Kennedy","year":"1997","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llaf144\/62842032\/llaf144.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/9\/1834\/62842032\/llaf144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/9\/1834\/62842032\/llaf144.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T16:47:05Z","timestamp":1755881225000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/50\/9\/1834\/8103798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,2]]},"references-count":10,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,4,2]]},"published-print":{"date-parts":[[2025,8,22]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llaf144","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,4,2]]}}}