{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:34:54Z","timestamp":1790109294773,"version":"4.0.1"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>There is an ongoing interest regarding the association of metabolic syndrome (MetS) and skin diseases. However, the link between MetS and pigmentation has not been extensively explored. In this review, we undertake a detailed discussion on the existing literature on this topic, the various implicated pathomechanisms and\/or molecular pathways, and highlight scope for further scientific exploration. A better understanding of the relationship between MetS and disorders of pigmentation contributes to early diagnosis and prevention, as well as providing clues for developing novel therapeutic strategies.<\/jats:p>","DOI":"10.1093\/ced\/llaf218","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:49:01Z","timestamp":1747356541000},"page":"1953-1962","source":"Crossref","is-referenced-by-count":2,"title":["Metabolic syndrome and pigmentation: a review of the connecting link"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8043-2721","authenticated-orcid":false,"given":"Abheek","family":"Sil","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology, and Leprosy, PKG Medical College and Hospital , Kolkata ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreya","family":"Poddar","sequence":"additional","affiliation":[{"name":"Consultant Dermatologist , Kolkata ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0841-9597","authenticated-orcid":false,"given":"Anupam","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Leprosy, KPC Medical College & Hospital , Kolkata ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diptarup","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Leprosy, KPC Medical College & Hospital , Kolkata ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"2025092509024662600_llaf218-B1","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2337\/diabetes.52.5.1210","article-title":"NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50\u2005years and older","volume":"52","author":"Alexander","year":"2003","journal-title":"Diabetes"},{"key":"2025092509024662600_llaf218-B2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4103\/ijd.IJD_728_20","article-title":"Skin and metabolic syndrome: an evidence based comprehensive review","volume":"66","author":"Fatima","year":"2021","journal-title":"Indian J Dermatol"},{"key":"2025092509024662600_llaf218-B3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.clindermatol.2017.09.008","article-title":"Acanthosis nigricans and the metabolic syndrome","volume":"36","author":"Karada\u011f","year":"2018","journal-title":"Clin Dermatol"},{"key":"2025092509024662600_llaf218-B4","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/jocd.13544","article-title":"Acanthosis nigricans: a review","volume":"19","author":"Das","year":"2020","journal-title":"J Cosmet Dermatol"},{"key":"2025092509024662600_llaf218-B5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2133.2004.06350.x","article-title":"Insulin-like growth factor binding protein-3 (IGFBP-3) localizes to and modulates proliferative epidermal keratinocytes in vivo","volume":"152","author":"Edmondson","year":"2005","journal-title":"Br J Dermatol"},{"key":"2025092509024662600_llaf218-B6","first-page":"591","article-title":"Facial acanthosis nigricans: a morphological marker of metabolic syndrome","volume":"62","author":"Panda","year":"2017","journal-title":"Indian J Dermatol"},{"key":"2025092509024662600_llaf218-B7","doi-asserted-by":"crossref","first-page":"498","DOI":"10.4103\/2229-5178.193898","article-title":"A descriptive study of facial acanthosis nigricans and its association with body mass index, waist circumference and insulin resistance using HOMA2 IR","volume":"7","author":"Verma","year":"2016","journal-title":"Indian Dermatol Online J"},{"key":"2025092509024662600_llaf218-B8","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1089\/met.2013.0145","article-title":"\u015eahin OZ. 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