{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:46:36Z","timestamp":1766047596287,"version":"3.44.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recent research has established an association between vitiligo and other autoimmune diseases. Given the systemic inflammation, there are likely other comorbidities with vitiligo that are not as well established. We identified 1074 patients with vitiligo and 4296 matched controls in the US All of Us database. Conditional logistic regression estimated the odds ratios (OR) and 95% confidence intervals (CI) of 29 selected comorbid conditions for patients with vitiligo compared with matched controls. The Benjamini\u2013Hochberg method was used to adjust P-values. In logistic regression, patients with vitiligo had significantly increased likelihoods of atherosclerotic disease (OR 1.78, 95% CI 1.48\u20132.14, P &amp;lt; 0.001), hypertension (OR 1.75, 95% CI 1.50\u20132.03, P &amp;lt; 0.001) and hyperlipidaemia (OR 2.32, 95% CI 1.99\u20132.72, P &amp;lt; 0.001). Patients with vitiligo additionally carried a significant bone and joint, autoimmune, endocrine and psychiatric comorbidity burden. This convergence highlights the multifaceted nature of vitiligo, prompting a need to investigate therapeutic approaches capable of addressing both vitiligo and its varied comorbidities.<\/jats:p>","DOI":"10.1093\/ced\/llaf228","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:59:53Z","timestamp":1747961993000},"page":"1856-1859","source":"Crossref","is-referenced-by-count":1,"title":["Vitiligo and associated comorbidities: a case\u2013control study in the All of Us database"],"prefix":"10.1093","volume":"50","author":[{"given":"Austin J","family":"Piontkowski","sequence":"first","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celina","family":"Dubin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sach","family":"Thakker","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Orloff","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-0566","authenticated-orcid":false,"given":"Camille M","family":"Powers","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0882-8163","authenticated-orcid":false,"given":"Benjamin","family":"Ungar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"2025082212471812900_llaf228-B1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.coi.2016.09.008","article-title":"Understanding mechanisms of autoimmunity through translational research in vitiligo","volume":"43","author":"Strassner","year":"2016","journal-title":"Curr Opin Immunol"},{"key":"2025082212471812900_llaf228-B2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/1346-8138.15582","article-title":"Association between vitiligo and subsequent risk of dementia: a population-based cohort study","volume":"48","author":"Chang","year":"2021","journal-title":"J Dermatol"},{"key":"2025082212471812900_llaf228-B3","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jid.2022.10.021","article-title":"Comorbidities in patients with vitiligo: a systematic review and meta-analysis","volume":"143","author":"Lee","year":"2023","journal-title":"J Invest Dermatol"},{"key":"2025082212471812900_llaf228-B4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jaad.2015.08.063","article-title":"Comorbid autoimmune diseases in patients with vitiligo: a cross-sectional study","volume":"74","author":"Gill","year":"2016","journal-title":"J Am Acad Dermatol"},{"issue":"S1","key":"2025082212471812900_llaf228-B5","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1111\/dth.12012","article-title":"Metabolic syndrome in vitiligo","volume":"25","author":"Pietrzak","year":"2012","journal-title":"Dermatol Ther"},{"key":"2025082212471812900_llaf228-B6","doi-asserted-by":"crossref","first-page":"11429","DOI":"10.3390\/ijms222111429","article-title":"Role of cytokines in vitiligo: pathogenesis and possible targets for old and new treatments","volume":"22","author":"Custurone","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025082212471812900_llaf228-B7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.semcdb.2021.05.014","article-title":"Interaction between bone and immune cells: implications for postmenopausal osteoporosis","volume":"123","author":"Fischer","year":"2022","journal-title":"Semin Cell Dev Biol"},{"key":"2025082212471812900_llaf228-B8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/1744666X.2019.1550358","article-title":"Cytokines: the yin and yang of vitiligo pathogenesis","volume":"15","author":"Singh","year":"2019","journal-title":"Exp Rev Clin Immunol"},{"key":"2025082212471812900_llaf228-B9","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1024\/0300-9831\/a000605","article-title":"Evidence of a possible therapeutic role of vitamin D in a cohort of adult Caucasian vitiligo patients","volume":"90","author":"Colucci","year":"2020","journal-title":"Int J Vitam Nutr Res"},{"key":"2025082212471812900_llaf228-B10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000339340","article-title":"Analysis of vitamin D receptor gene polymorphisms in vitiligo","volume":"224","author":"Ayding\u00f6z","year":"2012","journal-title":"Dermatology"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llaf228\/63300701\/llaf228.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/9\/1856\/63300701\/llaf228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/9\/1856\/63300701\/llaf228.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T16:47:25Z","timestamp":1755881245000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/50\/9\/1856\/8141161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":10,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,5,23]]},"published-print":{"date-parts":[[2025,8,22]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llaf228","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"type":"print","value":"0307-6938"},{"type":"electronic","value":"1365-2230"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,5,23]]}}}