{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:30:09Z","timestamp":1781299809828,"version":"3.54.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103768"],"award-info":[{"award-number":["82103768"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Commission","doi-asserted-by":"crossref","award":["21YF1441600"],"award-info":[{"award-number":["21YF1441600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>5-Aminolaevulinic acid photodynamic therapy (ALA-PDT) is an effective treatment for moderate-to-severe acne. However, it is associated with adverse effects, such as erythema, and requires multiple sessions. Supramolecular salicylic acid (SSA) is a type of chemical peel with good anti-inflammatory effects and mild adverse effects. Combining the two is novel for the treatment of acne vulgaris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the efficacy and safety of ALA-PDT followed by sequential 30% SSA treatment on moderate-to-severe acne vulgaris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 19 patients with moderate-to-severe acne vulgaris were enrolled in this prospective, randomized, split-face controlled study. The patients were treated once a week for a total of two treatments and followed up until 4 weeks after the final treatment. The study was registered on the Chinese Clinical Trial Register (ChiCTR2400079708).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ALA-PDT followed by sequential 30% SSA treatment significantly reduced the number of lesions compared with ALA-PDT treatment, especially for comedones and papules, without additional damage to the skin barrier. Despite transient mild pain reported by patients during SSA treatment, the protocol demonstrated significant attenuation of post-ALA-PDT erythema and ultraviolet-induced dermal pigmentation clusters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ALA-PDT followed by sequential 30% SSA enhances the efficacy of ALA-PDT in moderate-to-severe acne vulgaris and partially attenuates adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ced\/llaf230","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T07:32:15Z","timestamp":1748158335000},"page":"2439-2447","source":"Crossref","is-referenced-by-count":2,"title":["Effect of 5-aminolaevulinic acid photodynamic therapy followed by sequential 30% supramolecular salicylic acid treatment in moderate-to-severe acne vulgaris: a prospective, randomized, split-face controlled study"],"prefix":"10.1093","volume":"50","author":[{"given":"Yu","family":"Yan","sequence":"first","affiliation":[{"name":"Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dixin","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiru","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of 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