{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:26:53Z","timestamp":1786991213833,"version":"build-2736575974"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005897","name":"French Society of Dermatology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While the role of oncogenic alpha-human papillomavirus (\u03b1-HPV) types in anogenital and oral mucosal cancers is well established, their involvement in skin carcinogenesis remains unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the role of \u03b1-HPV in cutaneous squamous cell carcinoma (cSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 129 formalin-fixed, paraffin-embedded cSCC samples. The main outcomes were the proportion of \u03b1-HPV-positive cSCCs and the characterization of viral features, assessed through HPV typing and viral DNA integration analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 99 cases of invasive cSCCs and 30 cases of Bowen disease. HPV DNA was detected in 56.6% of samples. HPV from the alpha genus was identified in 25 samples (19.4%), with only a single \u03b1-HPV type detected in each positive sample. HPV16 was the main type, detected in 10 samples. Peripheral healthy skin tested negative in 10 out of 11 \u03b1-HPV-positive samples. Viral DNA was integrated into host-cell DNA in eight of nine HPV16-positive samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights a significant prevalence of \u03b1-HPV-positive samples among both invasive and in situ cSCC. The virological findings support a carcinogenic role of \u03b1-HPV in cSCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ced\/llaf264","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T07:58:40Z","timestamp":1750319920000},"page":"2147-2152","source":"Crossref","is-referenced-by-count":5,"title":["Detection of alpha-human papillomavirus types in cutaneous squamous cell carcinoma associated with markers of carcinogenesis: a retrospective study"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2100-2913","authenticated-orcid":false,"given":"Florence","family":"Brunet-Possenti","sequence":"first","affiliation":[{"name":"AP-HP, Bichat-Claude Bernard Hospital, Dermatology Department , Paris ,","place":["France"]},{"name":"INSERM, IAME, Paris Cit\u00e9 University , Paris 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