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We demonstrate that patients with PN have significantly higher odds of being a former or current smoker, overweight or obese, or heavy alcohol users. The presence of these lifestyle risk factors may compound multi-axis systemic inflammation known to drive PN, either predisposing patients to PN or accelerating progression of the condition.<\/jats:p>","DOI":"10.1093\/ced\/llaf281","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T11:41:31Z","timestamp":1753357291000},"page":"2271-2272","source":"Crossref","is-referenced-by-count":0,"title":["Cigarette smoking, obesity and alcohol use among patients with prurigo nodularis"],"prefix":"10.1093","volume":"50","author":[{"given":"Viviane","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD 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