{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:32:23Z","timestamp":1781623943197,"version":"3.54.5"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273559"],"award-info":[{"award-number":["82273559"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304052"],"award-info":[{"award-number":["82304052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M752264"],"award-info":[{"award-number":["2024M752264"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2022NSFSC1454"],"award-info":[{"award-number":["2022NSFSC1454"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Rosacea is a chronic dermatological condition primarily affecting the face, known for its links to the central nervous system and its significant social impact. However, the specific neurological underpinnings remain largely unexplored.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate the brain activity changes in patients with rosacea and their links with clinical symptoms and psychosocial measurements.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This cross-sectional study included 32 treatment-naive female patients with rosacea and 29 age- and sex-matched healthy control participants. Neuroimaging, and clinical and psychosocial assessments were conducted. Resting-state functional magnetic resonance imaging (rs-fMRI) data were analysed for amplitude of low-frequency fluctuations (ALFFs). We examined associations between ALFFs and clinical symptoms and psychosocial measures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Increased ALFF was observed in the prefrontal cortex (PFC) of patients with rosacea, particularly in the right superior frontal gyrus (SFG) and left orbital middle frontal gyrus (ORBmid) (voxel level P &amp;lt; 0.001, cluster level P &amp;lt; 0.05). The ALFF values of the right SFG were positively correlated with erythema scores (r = 0.395; P = 0.03). Meanwhile, activity in the left ORBmid correlated significantly with Social Avoidance and Distress Scale (r = 0.528; P = 0.002) and Social Appearance Anxiety Scale (r = 0.535, P = 0.002) scores. Mediation analysis showed that appearance anxiety mediates the association between the ALFF values of the left ORBmid and social avoidance (indirect effect = 0.217, 95% confidence interval 0.022\u20130.440; P &amp;lt; 0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study offers novel insights into rosacea's neuropathology, linking PFC activity with physical and psychosocial symptoms. The findings underscore the potential of targeting neuropsychosocial aspects in comprehensive rosacea management.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ced\/llaf291","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T17:18:40Z","timestamp":1750871920000},"page":"2022-2029","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the neural basis of rosacea: altered brain activity and its links with social anxiety"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9514-0740","authenticated-orcid":false,"given":"Deyu","family":"Song","sequence":"first","affiliation":[{"name":"Department of Dermatology, West China Hospital, Sichuan University , Chengdu ,","place":["China"]},{"name":"Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University , Chengdu ,","place":["China"]},{"name":"West China Medical Publishers, West China Hospital, Sichuan University , Chengdu ,","place":["China"]},{"name":"Research Unit of Psychoradiology, Chinese Academy of Medical Sciences , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5813-0308","authenticated-orcid":false,"given":"Yingying","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital of Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Dermatology, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Luo","sequence":"additional","affiliation":[{"name":"West China School of Medicine, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0914-5700","authenticated-orcid":false,"given":"Chenyang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China Hospital of Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, West China Hospital, Sichuan University , Chengdu ,","place":["China"]},{"name":"Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfeng","family":"Lai","sequence":"additional","affiliation":[{"name":"Mental Health Center, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Bao","sequence":"additional","affiliation":[{"name":"Mental Health Center, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, West China Hospital, Sichuan University , Chengdu ,","place":["China"]},{"name":"Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, West China Hospital, Sichuan University , Chengdu ,","place":["China"]},{"name":"Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-4871","authenticated-orcid":false,"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan 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