{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:35:03Z","timestamp":1772508903961,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Erythrasma is a chronic superficial bacterial infection caused by Corynebacterium minutissimum, predominantly affecting intertriginous areas. Cutaneous features include erythema, scaling and skin discoloration; notably, erythema may not manifest as classic redness in individuals with darker skin tones, instead appearing as subtle darkening, violaceous, or other colour changes. Diagnosis in all skin types is supported by the characteristic coral-red fluorescence observed under a Wood's lamp. Despite numerous available treatments, guidance on the most effective therapy is limited. A comprehensive review of studies published between 1971 and 2024, including randomized controlled trials and comparative clinical studies, revealed that both clotrimazole and fusidic acid are effective topical options, with fusidic acid providing faster symptom relief, greater reduction in Wood's lamp fluorescence and fewer side-effects. Clarithromycin was found to be more effective than erythromycin systemically, although gastrointestinal side effects can occur but are not widely reported in all patients. Topical therapies generally showed a better safety profile. Overall, treatment modalities for erythrasma are well tolerated, but there remains a shortage of large-scale randomized trials utilizing standardized outcomes, limiting the establishment of a clear consensus on optimal management.<\/jats:p>","DOI":"10.1093\/ced\/llaf307","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T08:41:21Z","timestamp":1752136881000},"page":"2139-2146","source":"Crossref","is-referenced-by-count":2,"title":["Erythrasma: a systematic review of interventions"],"prefix":"10.1093","volume":"50","author":[{"given":"Suganya","family":"Radhakrishnan","sequence":"first","affiliation":[{"name":"Department of Dermatology & STD, Sri Manakula Vinayagar Medical College and Hospital , Puducherry ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramamoorthy","family":"Logamoorthy","sequence":"additional","affiliation":[{"name":"Department of Dermatology & STD, Sri Manakula Vinayagar Medical College and Hospital , Puducherry ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaliaperumal","family":"Karthikeyan","sequence":"additional","affiliation":[{"name":"Department of Dermatology & STD, Sri Manakula Vinayagar Medical College and Hospital , Puducherry ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reenaa","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Sri Manakula Vinayagar Medical College and Hospital , Puducherry ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenifer Florence","family":"Mary J","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Mahatma Gandhi Medical College and Research Institute, SBV University , Puducherry ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"2025102707122420800_llaf307-B1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.17925\/ID.2023.2.1.19","article-title":"Erythrasma: a superficial cutaneous bacterial infection overlooked in clinical practice","volume":"2","author":"Rajkumar","year":"2023","journal-title":"touchREV Infect Dis"},{"key":"2025102707122420800_llaf307-B2","first-page":"e10733","article-title":"Erythrasma revisited: diagnosis, differential diagnoses, and comprehensive review of treatment","volume":"12","author":"Forouzan","year":"2020","journal-title":"Cureus"},{"key":"2025102707122420800_llaf307-B3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.34172\/jrcm.2020.032","article-title":"Treatment of erythrasma: a double-blinded randomized controlled trial on the clinical application of clotrimazole and sertaconazole","volume":"8","author":"Herizchi Ghadim","year":"2020","journal-title":"J Res Clin Med"},{"key":"2025102707122420800_llaf307-B4","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.14260\/jemds\/2016\/1248","article-title":"Erythrasma \u2013 a clinical and a comparative study of topical 2% clotrimazole cream vs topical 2% fusidic acid cream in a semi-urban setup in South India","volume":"5","author":"Prabhakar","year":"2016","journal-title":"J Evol Med Dent Sci"},{"key":"2025102707122420800_llaf307-B5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3109\/09546634.2011.594870","article-title":"A comparison between the effectiveness of erythromycin, single-dose clarithromycin and topical fusidic acid in the treatment of erythrasma","volume":"24","author":"Avci","year":"2013","journal-title":"J Dermatolog Treat"},{"key":"2025102707122420800_llaf307-B6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3109\/02813439109026579","article-title":"Systemic or local treatment of erythrasma? A comparison between erythromycin tablets and fucidin cream in general practice","volume":"9","author":"Hamann","year":"1991","journal-title":"Scand J Prim Health Care"},{"key":"2025102707122420800_llaf307-B7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1365-2230.1982.tb02473.x","article-title":"Double-blind comparison of the efficacy of tioconazole and miconazole for the treatment of fungal infection of the skin or erythrasma","volume":"7","author":"Clayton","year":"1982","journal-title":"Clin Exp Dermatol"},{"key":"2025102707122420800_llaf307-B8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-2230.1979.tb01640.x","article-title":"Treatment of erythrasma with miconazole","volume":"4","author":"Pitcher","year":"1979","journal-title":"Clin Exp Dermatol"},{"key":"2025102707122420800_llaf307-B9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2230.1979.tb01592.x","article-title":"A clinical double-blind trial of topical haloprogin and miconazole against superficial fungal infections","volume":"4","author":"Clayton","year":"1979","journal-title":"Clin Exp Dermatol"},{"key":"2025102707122420800_llaf307-B10","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2230.1976.tb01423.x","article-title":"A clinical double-blind trial of topical miconazole and clotrimazole against superficial fungal infections and erythrasma","volume":"1","author":"Clayton","year":"1976","journal-title":"Clin Exp Dermatol"},{"key":"2025102707122420800_llaf307-B11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-2133.1973.tb02978.x","article-title":"Comparison of clotrimazole cream, Whitfield's ointment and Nystatin ointment for the topical treatment of ringworm infections, pityriasis versicolor, erythrasma and candidiasis","volume":"89","author":"Clayton","year":"1973","journal-title":"Br J Dermatol"},{"key":"2025102707122420800_llaf307-B12","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1365-2133.1971.tb14051.x","article-title":"Sodium fusidate in the treatment of erythrasma","volume":"85","author":"Somerville","year":"1971","journal-title":"Br J Dermatol"},{"key":"2025102707122420800_llaf307-B13","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1365-2133.1970.tb02212.x","article-title":"The treatment of erythrasma in a hospital for the mentally subnormal","volume":"82","author":"Seville","year":"1970","journal-title":"Br J Dermatol"},{"key":"2025102707122420800_llaf307-B14","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/archderm.1968.01610110056010","article-title":"Treatment of erythrasma with an antibacterial soap","volume":"97","author":"Dodge","year":"1968","journal-title":"Arch Dermatol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llaf307\/63715866\/llaf307.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/11\/2139\/63715866\/llaf307.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/11\/2139\/63715866\/llaf307.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:12:31Z","timestamp":1761563551000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/50\/11\/2139\/8196029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,10]]},"references-count":14,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,7,10]]},"published-print":{"date-parts":[[2025,10,27]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llaf307","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,7,10]]}}}