{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:53:23Z","timestamp":1793642003973,"version":"4.5.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Shanghai Ruizhi Medical Technology Co. Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rosacea is a chronic inflammatory skin disorder with a complex aetiology involving genetic, immunological and environmental factors. Although various treatments are available, managing papulopustular lesions remains challenging. Salicylic acid, known for its anti-inflammatory properties, has been used in dermatology for decades, but its efficacy in treating rosacea needs further exploration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the effectiveness and safety of 30% supramolecular salicylic acid (SSA) in treating papulopustular rosacea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective multicentre, randomized, double-blind, placebo-controlled trial involving 480 patients aged 18\u201360\u2005years with papulopustular rosacea. Participants were randomized 1 : 1 to receive either 30% SSA or placebo every 2 weeks for 6 weeks, with follow-up assessments up to week 8. The study assessed primary and secondary efficacy endpoints, including lesion reduction rates, Investigator\u2019s Global Assessment (IGA) and Investigator\u2019s Severity Assessment (ISA) scores, VISIA\u00ae red area improvements and skin barrier functions, and evaluated safety and tolerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The SSA group showed a significant improvement in the primary efficacy endpoint at week 8, with efficacy rates of 51.3% [full-analysis set (FAS)] and 59.9% [per-protocol set (PPS)], compared with 18.3% (FAS) and 20.5% (PPS) in the placebo group (P &amp;lt; 0.001 for both). Secondary endpoints also favoured SSA, demonstrating improved lesion reduction, IGA and ISA scores, and skin condition. Safety profiles were comparable between the SSA and placebo groups, with no significant difference in adverse event rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings highlight the superior efficacy of 30% SSA in improving papulopustular rosacea symptoms compared with a placebo, coupled with a favourable safety and tolerability profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ced\/llaf316","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:01:58Z","timestamp":1753315318000},"page":"2410-2417","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of supramolecular salicylic acid in the treatment of papulopustular rosacea: a multicentre randomized, double-blind, placebo-controlled superiority study"],"prefix":"10.1093","volume":"50","author":[{"given":"Xian","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Dermatology & Venereology, West China Hospital, Sichuan University , Chengdu ,","place":["China"]},{"name":"Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6571-6649","authenticated-orcid":false,"given":"Juan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianjin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-E","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqin","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enpin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"2025112512422287300_llaf316-B1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/bjd.17590","article-title":"Interventions 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