{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T12:26:53Z","timestamp":1761568013455,"version":"build-2065373602"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,27]]},"abstract":"<jats:p>We highlight the development of calcinosis cutis in a 66-year-old woman with a history of dermatomyositis (DM) and breast cancer treated with radiotherapy. The use of radiotherapy in a patient with DM carries a heightened risk for calcinosis cutis and can cause a dermatosis with anomalous clinical features. We suggest that the early onset of symptomatic calcification observed in this patient was precipitated by a \u2018double hit\u2019 of radiotherapy and DM with a pathogenesis analogous to radiation recall dermatitis.<\/jats:p>","DOI":"10.1093\/ced\/llaf327","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T11:15:06Z","timestamp":1752837306000},"page":"2305-2307","source":"Crossref","is-referenced-by-count":0,"title":["Calcinosis cutis in the context of dermatomyositis and radiotherapy: a double hit for heterotopic calcification"],"prefix":"10.1093","volume":"50","author":[{"given":"Tenzin S","family":"Brookes","sequence":"first","affiliation":[{"name":"Dermatology Department, King\u2019s College Hospital NHS Foundation Trust , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shafiah A M","family":"Gafoor","sequence":"additional","affiliation":[{"name":"Dermatology Department, King\u2019s College Hospital NHS Foundation Trust , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Philippidou","sequence":"additional","affiliation":[{"name":"Histopathology Department, King\u2019s College Hospital NHS Foundation Trust , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Gordon","sequence":"additional","affiliation":[{"name":"Rheumatology Department, King\u2019s College Hospital NHS Foundation Trust , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Creamer","sequence":"additional","affiliation":[{"name":"Dermatology Department, King\u2019s College Hospital NHS Foundation Trust , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,19]]},"reference":[{"key":"2025102707130015200_llaf327-B1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1001\/archdermatol.2011.2052","article-title":"Calcinosis cutis occurring in association with autoimmune connective tissue disease: the Mayo Clinic experience with 78 patients, 1996\u20132009","volume":"148","author":"Balin","year":"2012","journal-title":"Arch Dermatol"},{"key":"2025102707130015200_llaf327-B2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/medicina60030399","article-title":"Symptomatic calcifications after mastectomy: a rare case report with a review of the literature","volume":"60","author":"\u017dateck\u00fd","year":"2024","journal-title":"Medicina (Kaunas)"},{"key":"2025102707130015200_llaf327-B3","doi-asserted-by":"crossref","first-page":"103061","DOI":"10.1016\/j.jaut.2023.103061","article-title":"Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis","volume":"138","author":"Duvvuri","year":"2023","journal-title":"J Autoimmun"},{"key":"2025102707130015200_llaf327-B4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.5152\/eurjrheum.2016.15080","article-title":"Breast calcinosis in a patient with dermatomyositis","volume":"4","author":"Namas","year":"2017","journal-title":"Eur J Rheumatol"},{"key":"2025102707130015200_llaf327-B5","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s00403-024-03148-0","article-title":"Treatment of calcinosis cutis associated with autoimmune connective tissue diseases","volume":"316","author":"Lau","year":"2024","journal-title":"Arch Dermatol Res"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llaf327\/63798908\/llaf327.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/11\/2305\/63798908\/llaf327.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/50\/11\/2305\/63798908\/llaf327.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:13:20Z","timestamp":1761563600000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/50\/11\/2305\/8207152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,19]]},"references-count":5,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,7,19]]},"published-print":{"date-parts":[[2025,10,27]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llaf327","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"type":"print","value":"0307-6938"},{"type":"electronic","value":"1365-2230"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,7,19]]}}}