{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:53:54Z","timestamp":1792176834209,"version":"4.4.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"funds from the National Nature Science Foundation of China","doi-asserted-by":"publisher","award":["81903190"],"award-info":[{"award-number":["81903190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YG2022QN040"],"award-info":[{"award-number":["YG2022QN040"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis (PSO) and eczema are inflammatory skin disorders with distinct immune mechanisms. PSO is mainly driven by T helper (Th)17 immune responses, while eczema, notably atopic dermatitis (AD), is Th2 mediated. Spongiotic psoriasiform dermatitis (SD\/PSO), a hybrid phenotype of both conditions, lacks precise immunophenotypic characterization and specific treatment strategies. Existing studies have shown that some patients with SD\/PSO exhibit a poor response to conventional and single T-cell axis-targeted therapies (such as Th2\/Th17 inhibitors), suggesting cross-activation of immune pathways, which urgently requires more targeted intervention strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the immunological and differentiation profiles of SD\/PSO, clarify its differences from classical PSO and AD, and identify alternative therapies for conventional therapy-resistant patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Four patients with SD\/PSO were evaluated. Histopathological analysis and tyramide signal amplification-based multiplex immunofluorescence assay were performed to assess immune profiles and keratinocyte differentiation profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In four patients with SD\/PSO, conventional therapies showed inadequate response. Three patients experienced lesion exacerbation with interleukin (IL)-17A inhibitors. Immunomarker analysis revealed mixed Th17\/Th2 activation: Th17 markers (IL-17A, IL-23, IL-36A\/G) were comparably elevated to PSO, while IL-4 levels matched AD and IL-13 exhibited moderate-level expression (between PSO and AD). SD\/PSO lesions exhibited PSO-like epidermal differentiation with Janus kinase\u2013signal transducer and activator of transcription (JAK-STAT) hyperactivation and JAK inhibitor treatment induced significant clinical improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SD\/PSO represents a mixed AD-PSO immunophenotype with PSO-like differentiation patterns, characterized by coactivated Th17\/Th2 pathways and JAK-STAT hyperactivation. JAK inhibitors effectively treat patients with SD\/PSO by suppressing multi-T-cell axis-targeted inflammatory signals and blocking epidermal hyperproliferation, establishing JAK-STAT inhibition as a targeted strategy. Larger studies are needed to validate results and explore combination therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ced\/llaf336","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T11:48:59Z","timestamp":1753530539000},"page":"2431-2438","source":"Crossref","is-referenced-by-count":7,"title":["Spongiotic psoriasiform dermatitis with dual features of eczema and psoriasis: Janus kinase inhibition as a potential therapeutic option"],"prefix":"10.1093","volume":"50","author":[{"given":"Wenjie","family":"Cheng","sequence":"first","affiliation":[{"name":"Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine , Shanghai ,","place":["China"]},{"name":"Department of Dermatology, Shanghai Jiaotong University School of Medicine , Shanghai ,","place":["China"]},{"name":"Institute of Dermatology, Shanghai Jiaotong University School of Medicine , Shanghai 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