{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:16:25Z","timestamp":1787008585517,"version":"build-2736575974"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100022600","name":"Wan Fang Hospital","doi-asserted-by":"publisher","award":["113-wf-eva-30"],"award-info":[{"award-number":["113-wf-eva-30"]}],"id":[{"id":"10.13039\/501100022600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acne is a common dermatological disease, characterized by the presence of comedones, papules, pustules or purulent cysts on seborrhoeic areas. Probiotics are a substrate that is selectively utilized by host microorganisms, conferring a health benefit. It has been demonstrated as an effective treatment for dermatological disorders. However, the effects of probiotics on acne remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This systematic review and meta-analysis investigated the therapeutic difference (disease severity grading and number of lesions) between oral probiotics and control (placebo) in patients with acne.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search was conducted using PubMed, Embase and Cochrane Library for randomized trials published before February 2025, comparing probiotics with other interventions, including pharmacological treatments or placebo, in patients with acne.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified a total of 632 articles initially, and 9 studies involving 623 patients were included in the systematic review. Seven studies were further included in quantitative analysis. After the 4-week intervention, slight differences were observed in the number of inflammatory or noninflammatory lesions between the probiotics and control groups. However, after the 12-week intervention, probiotics significantly alleviated disease severity grading (standard mean difference \u22121.38, 95% confidence interval \u22122.69 to \u22120.08); decreased the total number of lesions (mean difference \u221210.4, 95% CI \u221216.2 to \u22124.51), the number of inflammatory lesions and the number of noninflammatory lesions; and improved skin hydration and sebum content compared with control. Moreover, no major adverse effects of probiotics were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Probiotics may exert therapeutic effects in patients with acne.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ced\/llaf388","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T11:33:10Z","timestamp":1755603190000},"page":"68-77","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of oral probiotics in patients with acne: a\u00a0systematic review and meta-analysis of randomized trials"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5776-1922","authenticated-orcid":false,"given":"Ho-Wei","family":"Lin","sequence":"first","affiliation":[{"name":"Department of General Medicine, Wan Fang Hospital, Taipei Medical University , Taipei ,","place":["Taiwan"]},{"name":"School of Medicine, College of Medicine, Taipei Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka-Wai","family":"Tam","sequence":"additional","affiliation":[{"name":"Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University , Taipei ,","place":["Taiwan"]},{"name":"Cochrane Taiwan, Taipei Medical University , Taipei ,","place":["Taiwan"]},{"name":"Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University , Taipei ,","place":["Taiwan"]},{"name":"Division of General Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Research Center of Big Data and Meta-Analysis, Wan Fang Hospital, Taipei Medical University , Taipei ,","place":["Taiwan"]},{"name":"Department of Dermatology, Wan Fang Hospital, Taipei Medical University , Taipei ,","place":["Taiwan"]},{"name":"Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"2025122312174368400_llaf388-B1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(11)60321-8","article-title":"Acne vulgaris","volume":"379","author":"Williams","year":"2012","journal-title":"Lancet"},{"key":"2025122312174368400_llaf388-B2","first-page":"475","article-title":"Acne vulgaris: diagnosis and treatment","volume":"100","author":"Oge","year":"2019","journal-title":"Am Fam Physician"},{"key":"2025122312174368400_llaf388-B3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/jdv.19540","article-title":"Acne microbiome: from phyla to phylotypes","volume":"38","author":"Dreno","year":"2024","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025122312174368400_llaf388-B4","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3390\/healthcare9060668","article-title":"Acne vulgaris and intake of selected dietary nutrients \u2013 a summary of information","volume":"9","author":"Podg\u00f3rska","year":"2021","journal-title":"Healthcare (Basel)"},{"key":"2025122312174368400_llaf388-B5","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/jid.2013.446","article-title":"The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions","volume":"134","author":"Hay","year":"2014","journal-title":"J Invest Dermatol"},{"key":"2025122312174368400_llaf388-B6","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.3390\/molecules21081063","article-title":"Treatment modalities for acne","volume":"21","author":"Fox","year":"2016","journal-title":"Molecules"},{"key":"2025122312174368400_llaf388-B7","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/bjd.21739","article-title":"A systematic review and network meta-analysis of topical pharmacological, oral pharmacological, physical and combined treatments for acne vulgaris","volume":"187","author":"Mavranezouli","year":"2022","journal-title":"Br J Dermatol"},{"key":"2025122312174368400_llaf388-B8","first-page":"273","article-title":"Adverse effects of retinoids. 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