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While metformin is primarily used for managing type 2 diabetes, recent studies suggest it has the ability to modulate fibrosis by activating AMP-activated protein kinase, offering a potential treatment approach for CCCA. This review examines current evidence and mechanistic insights into the potential role of metformin in modifying the fibrotic processes in CCCA.<\/jats:p>","DOI":"10.1093\/ced\/llaf400","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:41:39Z","timestamp":1756467699000},"page":"142-143","source":"Crossref","is-referenced-by-count":0,"title":["Metformin for treating central centrifugal cicatricial alopecia: emerging evidence and mechanistic insights"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3473-7946","authenticated-orcid":false,"given":"Oluwamayowa","family":"Aboluwarin","sequence":"first","affiliation":[{"name":"Department of Dermatology, Royal Derby Hospital , Derby ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"2025122312172796300_llaf400-B1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s40257-022-00740-w","article-title":"Beyond the hot comb: updates in epidemiology, pathogenesis, and treatment of central centrifugal cicatricial alopecia from 2011 to 2021","volume":"24","author":"George","year":"2023","journal-title":"Am J Clin Dermatol"},{"key":"2025122312172796300_llaf400-B2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jdcr.2019.12.008","article-title":"Hair regrowth in 2 patients with recalcitrant central centrifugal cicatricial alopecia after use of topical metformin","volume":"6","author":"Araoye","year":"2020","journal-title":"JAAD Case Rep"},{"key":"2025122312172796300_llaf400-B3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/ijd.17345","article-title":"Treatment of central centrifugal cicatricial alopecia with topical metformin 10% cream: case report and literature review","volume":"64","author":"Granja","year":"2025","journal-title":"Int J Dermatol"},{"key":"2025122312172796300_llaf400-B4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jdcr.2024.12.025","article-title":"Adjuvant use of topical metformin with standard therapies in recalcitrant central centrifugal cicatricial alopecia: a case series","volume":"57","author":"Williams","year":"2025","journal-title":"JAAD Case Rep"},{"key":"2025122312172796300_llaf400-B5","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1001\/jamadermatol.2024.3062","article-title":"Low-dose metformin and profibrotic signature in central centrifugal cicatricial alopecia","volume":"160","author":"Bao","year":"2024","journal-title":"JAMA Dermatol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llaf400\/64196729\/llaf400.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/51\/1\/142\/64196729\/llaf400.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/51\/1\/142\/64196729\/llaf400.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T17:17:35Z","timestamp":1766510255000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/51\/1\/142\/8246377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,3]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,9,3]]},"published-print":{"date-parts":[[2025,12,23]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llaf400","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"type":"print","value":"0307-6938"},{"type":"electronic","value":"1365-2230"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,9,3]]}}}