{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:13:35Z","timestamp":1788495215074,"version":"build-2803163510"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reflectance confocal microscopy (RCM) criteria for the in vivo diagnosis of superficial basal cell carcinoma (sBCC) lesions have been validated, with studies indicating a high level of diagnostic sensitivity. However, there remains a paucity of data regarding the preservation of or changes in RCM features following biopsy or treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To use RCM to prospectively image biopsy-confirmed sBCC at baseline and 12 weeks post-treatment to determine clearance and identify any associated RCM features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten patients with biopsy-confirmed sBCC participated in this study. Clinical examination, dermoscopy and RCM imaging were performed at baseline, prior to treatment and 12 weeks post-treatment, with a 1064 Nd-YAG laser. Following treatment, RCM features were compared with clinical and histological findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Statistically significant changes in RCM features at baseline and follow-up included tumour islands with hyperreflective aggregates, dark silhouettes, peripheral palisading, peritumoral clefting, and dermal inflammatory cells. There were no significant changes in nuclear streaming, fibrosis or vasculature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The features of nuclear streaming, fibrosis and dilated vessels may be observed during RCM imaging of biopsy-confirmed sBCC at baseline and post-treatment and should be interpreted with caution. Additional studies are needed to further validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ced\/llaf407","type":"journal-article","created":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T11:32:53Z","timestamp":1757244773000},"page":"244-249","source":"Crossref","is-referenced-by-count":1,"title":["Reflectance confocal microscopy for monitoring treatment response in superficial basal cell carcinoma: diagnostic challenges due to scar formation"],"prefix":"10.1093","volume":"51","author":[{"given":"Marie","family":"Clark","sequence":"first","affiliation":[{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Wuennenberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalal","family":"Maghfour","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittani","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane M","family":"Grant-Kels","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Connecticut School of Medicine , Farmington Avenue, CT ,","place":["USA"]},{"name":"Department of Dermatology, University of Florida College of Medicine , Gainesville, FL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Memorial Sloan Kettering Cancer Center , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Ozog","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Medicine, College of Human Medicine, Michigan State University , East Lansing, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indermeet","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Medicine, College of Human Medicine, Michigan State University , East Lansing, MI ,","place":["USA"]},{"name":"Wayne State University, Department of Physics and Astronomy , Detroit, MI 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