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The patient received three infusions of spesolimab (900\u2005mg each), an interleukin-36 receptor antagonist recently approved for generalized pustular psoriasis and showed a rapid response. Seven months of follow-up from the first infusion, the clinical improvement was significant and there were no adverse effects during or after spesolimab treatment. Interestingly, spesolimab reduced the need for steroids and immunosuppressants, and alleviated pustular symptoms.<\/jats:p>","DOI":"10.1093\/ced\/llaf448","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T07:54:06Z","timestamp":1762761246000},"page":"294-296","source":"Crossref","is-referenced-by-count":0,"title":["Successful treatment of refractory and recurrent pyoderma gangrenosum with pustules and ulcers using spesolimab"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3890-5067","authenticated-orcid":false,"given":"Xinyue","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Dermatovenereology, Tianjin Medical University General Hospital\/Tianjin Institute of Sexually Transmitted Disease , Tianjin ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisha","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, 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