{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:09:01Z","timestamp":1769576941276,"version":"3.49.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,27]]},"abstract":"<jats:p>This case report describes a 63-year-old man presenting with facial and leg oedema following a tick bite, in the absence of systemic symptoms. Despite a negative Borrelia DNA polymerase chain reaction test, the patient was diagnosed with acrodermatitis chronica atrophicans (ACA) based on clinical, serological (positive IgG for Borrelia burgdorferi) and histopathological findings (lymphoplasmacytic infiltrate). The patient showed a favourable response to doxycycline, with full resolution of symptoms within 1\u2005month. ACA typically evolves from an inflammatory phase to atrophy and fibrosis. This case highlights that facial oedema may represent an early manifestation of ACA, facilitating earlier diagnosis and intervention. Furthermore, positron emission tomography\/computed tomography imaging may offer valuable insights into early ACA detection.<\/jats:p>","DOI":"10.1093\/ced\/llaf450","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:03:59Z","timestamp":1760097839000},"page":"286-288","source":"Crossref","is-referenced-by-count":0,"title":["Atypical facial oedema in acrodermatitis chronica atrophicans: a potential clue for early diagnosis in Lyme disease"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4792-4006","authenticated-orcid":false,"given":"Ane Carrera","family":"Gabilondo","sequence":"first","affiliation":[{"name":"Department of Dermatology, University Clinic of Navarra , Pamplona ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nerea Fern\u00e1ndez","family":"Ros","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Clinic of Navarra , 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