{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:31:55Z","timestamp":1787581915228,"version":"build-2736575974"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thin melanomas (TMs) are typically associated with favourable outcomes, but a subset of patients experience recurrence and worse survival. Prognostic factors for recurrence in TM remain inadequately characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify clinical and histopathological factors associated with recurrence and explore implications for follow-up strategies in TM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study included 308 patients with TM (Breslow thickness 0.1\u20131\u2005mm) treated at two medical institutions between 1998 and 2017. Patients were stratified into groups with recurrence (n = 53) and no recurrence (n = 255). Clinical and histopathological variables were analysed, and survival outcomes were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recurrence (vs. no recurrence) was associated with nodular histology (13% vs. 3.1%, P = 0.02), presence of ulceration (17% vs. 2.7%, P &amp;lt; 0.001) and higher mitotic rate (mean 2.1 vs. 0.6 mitoses mm\u22122, P &amp;lt; 0.001). Ultrathin melanoma (Breslow \u2264 0.5\u2005mm) was protective against recurrence (hazard ratio 0.08, P &amp;lt; 0.001). Recurrence (vs. no recurrence) reduced 10-year overall survival (62% vs. 95.7%, P &amp;lt; 0.001) and melanoma-specific survival (64% vs. 100%, P &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prognostic factors such as ulceration, mitotic rate and histological subtype should guide individualized follow-up strategies. Ultrathin melanomas may require less intensive monitoring, while melanomas &amp;gt; 0.5\u2005mm could benefit from extended follow-up beyond current guidelines. Tailoring surveillance based on recurrence risk could improve outcomes and quality of care for patients with TM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ced\/llaf499","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:01:03Z","timestamp":1762520463000},"page":"555-562","source":"Crossref","is-referenced-by-count":2,"title":["Identifying high-risk features and improving follow-up strategies in thin melanoma: a retrospective cohort study"],"prefix":"10.1093","volume":"51","author":[{"given":"Antonella","family":"Vecchiato","sequence":"first","affiliation":[{"name":"Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Cozzolino","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health (DCTV), University of Padova , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2862-8014","authenticated-orcid":false,"given":"Paolo","family":"Del Fiore","sequence":"additional","affiliation":[{"name":"Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fortunato","family":"Cassalia","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Department of Medicine, University of Padua , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PierPaola","family":"Vallese","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences (DISCOG), University of Padua , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6063-7930","authenticated-orcid":false,"given":"Chiara","family":"Trevisiol","sequence":"additional","affiliation":[{"name":"Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Rastrelli","sequence":"additional","affiliation":[{"name":"Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS , Padua ,","place":["Italy"]},{"name":"Department of Surgical, Oncological and Gastroenterological Sciences (DISCOG), University of Padua , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Salizzato","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Oncology 2 Unit, Veneto Institute of Oncology IOV-IRCCS , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Piccin","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Oncology 2 Unit, Veneto Institute of Oncology IOV-IRCCS , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Russo","sequence":"additional","affiliation":[{"name":"Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2216-3807","authenticated-orcid":false,"given":"Alessandra","family":"Buja","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health (DCTV), University of Padova , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Pigozzo","sequence":"additional","affiliation":[{"name":"Melanoma Unit, Oncology 2 Unit, Veneto Institute of Oncology IOV-IRCCS , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Cappellesso","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Unit, Padua University Hospital , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Alaibac","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Department of Medicine, University of Padua , Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Mocellin","sequence":"additional","affiliation":[{"name":"Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS , Padua 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