{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:59:20Z","timestamp":1777046360915,"version":"3.51.4"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment resistance in tinea corporis has emerged recently, resulting in unresponsive infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the resistance of recalcitrant dermatophytoses on glabrous skin and to understand the situation in Sri Lanka.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A descriptive, observational, cross-sectional study was conducted involving nine hospitals representing all nine provinces in Sri Lanka over 6\u2005months, starting from June 2019. All patients with dermatophyte infections in the glabrous skin were included. Sociodemographic characteristics, symptoms and prior treatment were collected. Antifungal sensitivity testing was done by a method adopted from EUCAST E.DEF 9.3 (2015). Quality control was done to ensure the accuracy of results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 127 isolates of dermatophytes for testing antifungal sensitivity. Trichophyton mentagrophytes comprised the majority, with 79 isolates, while there were 48 isolates of T. rubrum. The mean minimum inhibitory concentration (50th percentile; MIC50) of terbinafine was 0.064\u2005g mL\u20131 for T. mentagrophytes. A significant number of isolates (8 of 32, 25%) had an MIC higher than the epidemiological cutoff of 0.125\u2005g mL\u20131 set by EUCAST for terbinafine, indicating a higher likelihood of clinical failure. The MIC50 for itraconazole was 0.25\u2005g mL\u20131. Considering the epidemiological cutoff of 0.25\u2005g mL\u20131 for T. mentagrophytes, 33 of 79 (42%) isolates tested for itraconazole were higher.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Itraconazole may need to be used in the treatment, with close monitoring of the response of the patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ced\/llaf551","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T12:33:56Z","timestamp":1765802036000},"page":"862-866","source":"Crossref","is-referenced-by-count":0,"title":["Emergence of resistant tinea corporis in a low socioeconomic setting"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3049-3585","authenticated-orcid":false,"given":"Harshani","family":"Thabrew","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, University of Ruhuna , Galle ,","place":["Sri Lanka"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayani","family":"Madarasinghe","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Colombo East Base Hospital , Mulleriyawa ,","place":["Sri Lanka"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surammika","family":"Eriyagama","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Base Hospital , Nawalapitiya ,","place":["Sri Lanka"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreenika","family":"Weliange","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Faculty of Medicine, University of Colombo ,","place":["Sri Lanka"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Reinel","sequence":"additional","affiliation":[{"name":"Office for Mycology and Tropical Dermatology , Basselweg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Primali","family":"Jayasekera","sequence":"additional","affiliation":[{"name":"Department of Mycology, Medical Research Institute , Colombo 8 ,","place":["Sri Lanka"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"2026042410413351500_llaf551-B1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3390\/jof8070757","article-title":"Trichophyton indotineae \u2013 an emerging pathogen causing recalcitrant dermatophytoses in India and worldwide \u2013 a multidimensional perspective","volume":"8","author":"Uhrla\u00df","year":"2022","journal-title":"J Fungi (Basel)"},{"key":"2026042410413351500_llaf551-B2","doi-asserted-by":"crossref","first-page":"586","DOI":"10.25259\/IJDVL_112_2022","article-title":"Trichophyton mentagrophytes ITS genotype VIII and Trichophyton indotineae: a terminological maze, or is it?","volume":"88","author":"Nenoff","year":"2022","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2026042410413351500_llaf551-B3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cmi.2020.08.042","article-title":"Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST). How to: perform antifungal susceptibility testing of microconidia-forming dermatophytes following the new reference EUCAST method E.Def 11.0, exemplified by Trichophyton","volume":"27","author":"Arendrup","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"2026042410413351500_llaf551-B4","first-page":"125","article-title":"Interlaboratory evaluation of the E test for antifungal susceptibility testing of dermatophytes","volume":"41","author":"Fernandez-Torres","year":"2003","journal-title":"Med Mycol"},{"key":"2026042410413351500_llaf551-B5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4103\/idoj.IDOJ_146_19","article-title":"Antifungal drug susceptibility testing of dermatophytes: laboratory findings to clinical implications","volume":"10","author":"Dogra","year":"2019","journal-title":"Indian Dermatol Online J"},{"key":"2026042410413351500_llaf551-B6","first-page":"24","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi","author":"Clinical and Laboratory Standards Institute","year":"2017","edition":"3rd edn"},{"key":"2026042410413351500_llaf551-B7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4269\/ajtmh.21-1022","article-title":"Characterization of recalcitrant dermatophytosis in a multicenter study in Sri Lanka","volume":"107","author":"Madarasingha","year":"2022","journal-title":"Am J Trop Med Hyg"},{"key":"2026042410413351500_llaf551-B8","volume-title":"Atlas of Clinical Fungi","author":"de Hoog","year":"2020","edition":"4th edn"},{"key":"2026042410413351500_llaf551-B9","doi-asserted-by":"crossref","first-page":"575","DOI":"10.4269\/ajtmh.24-0027","article-title":"Dermatophytosis caused by Trichophyton indotineae (Trichophyton mentagrophytes ITS genotype VIII) in Sri Lanka","volume":"111","author":"Madarasingha","year":"2024","journal-title":"Am J Trop Med Hyg"},{"key":"2026042410413351500_llaf551-B10","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/myc.12772","article-title":"High terbinafine resistance in Trichophyton interdigitale isolates in Delhi, India harbouring mutations in squalene epoxidase gene","volume":"61","author":"Singh","year":"2018","journal-title":"Mycoses"},{"key":"2026042410413351500_llaf551-B11","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3390\/antibiotics14050472","article-title":"Terbinafine resistance in Trichophyton rubrum and Trichophyton indotineae: a literature review","volume":"14","author":"Gupta","year":"2025","journal-title":"Antibiotics"},{"key":"2026042410413351500_llaf551-B12","doi-asserted-by":"crossref","first-page":"768","DOI":"10.3390\/jof10110768","article-title":"Trichophyton mentagrophytes ITS genotype VIII\/Trichophyton indotineae infection and antifungal resistance in Bangladesh","volume":"10","author":"Bhuiyan","year":"2024","journal-title":"J Fungi (Basel)"},{"key":"2026042410413351500_llaf551-B13","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1086\/342384","article-title":"Has antifungal susceptibility testing come of age?","volume":"35","author":"Pfaller","year":"2002","journal-title":"Clin Infect Dis"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llaf551\/65915559\/llaf551.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/51\/5\/862\/65915559\/llaf551.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/51\/5\/862\/65915559\/llaf551.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:41:41Z","timestamp":1777041701000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/51\/5\/862\/8381338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,16]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,12,16]]},"published-print":{"date-parts":[[2026,4,24]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llaf551","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2025,12,16]]}}}