{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T03:04:02Z","timestamp":1779764642731,"version":"3.53.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Keratinocyte cancer (KC) is the most common malignancy worldwide. Surgical excision is the primary treatment, with clear margin delineation critical for oncological and cosmetic outcomes. Dermoscopy, well established for diagnosis, has recently been included in updated British guidelines as an alternative method for surgical margin planning and may offer improved border visualization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To update the existing evidence on dermoscopy-guided excision of KC, focusing on margin control and recurrence risk and incorporating newly published studies and re-evaluating its use considering evolving guideline recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines. PubMed, EMBASE and CENTRAL were searched to October 2024. Eligible studies compared dermoscopy-guided with conventional surgical excision of histologically confirmed KC. The primary outcome was the\u00a0incomplete excision rate. Risk of bias was assessed using ROBINS-I, and meta-analysis was\u00a0conducted using a DerSimonian\u2013Laird random-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten studies (1151 patients; 1186 lesions) were included; 4 contributed to meta-analysis. Most focused on basal cell carcinoma; squamous cell carcinoma data were limited. Dermoscopy was associated with improved surgical precision and reduced incomplete excision (pooled odds ratio 0.30, 95% confidence intervals 0.27\u20130.34, P &amp;lt; 0.001; I\u00b2 = 0%, P &amp;gt; 0.99), although all studies were observational and at moderate to serious risk of bias. Narrower margins were often achieved without compromising recurrence outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dermoscopy may enhance preoperative planning in KC excision, but evidence remains limited by methodological constraints. These findings support further high-quality trials to confirm clinical utility and define its role in future surgical guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ced\/llag003","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:48:09Z","timestamp":1767962889000},"page":"977-987","source":"Crossref","is-referenced-by-count":0,"title":["The role of dermoscopy in optimizing surgical margins for keratinocyte cancers: updated evidence from a systematic review and meta-analysis"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5244-8155","authenticated-orcid":false,"given":"Christos","family":"Vosinakis","sequence":"first","affiliation":[{"name":"Research & Development Department, Hull University Teaching Hospitals NHS Trust , Cottingham ,","place":["UK"]},{"name":"Department of Plastic and Reconstructive Surgery, Hull University Teaching Hospitals NHS Trust , Cottingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna R","family":"Hurley","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Sheffield Teaching Hospitals NHS Foundation Trust , Sheffield ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M","family":"Pinder","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Hull University Teaching Hospitals NHS Trust , Cottingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo L","family":"Matteucci","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Hull University Teaching Hospitals NHS Trust , Cottingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-1414","authenticated-orcid":false,"given":"Joshua\u00a0P","family":"Totty","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Hull University Teaching Hospitals NHS Trust , Cottingham ,","place":["UK"]},{"name":"Centre for Clinical Sciences, Hull York Medical School , Hull ,","place":["UK"]},{"name":"University of Hull , Hull ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,10]]},"reference":[{"key":"2026052522575014900_llag003-B1","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1186\/s12885-022-09940-3","article-title":"Changing trends in the disease burden of non-melanoma skin cancer globally from 1990 to 2019 and its predicted level in 25\u2005years","volume":"22","author":"Hu","year":"2022","journal-title":"BMC Cancer"},{"key":"2026052522575014900_llag003-B2","first-page":"110","article-title":"Non-melanoma skin cancer: statistical associations between clinical parameters","volume":"48","author":"Ciuciulete","year":"2022","journal-title":"Curr Health Sci J"},{"key":"2026052522575014900_llag003-B3","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1002\/ski2.61","article-title":"An updated report on the incidence and epidemiological trends of keratinocyte cancers in the United Kingdom 2013\u20132018","volume":"1","author":"Kwiatkowska","year":"2021","journal-title":"Skin Health Dis"},{"key":"2026052522575014900_llag003-B4","author":"Cancer Research UK"},{"key":"2026052522575014900_llag003-B5","doi-asserted-by":"crossref","first-page":"e3300","DOI":"10.1097\/GOX.0000000000003300","article-title":"Treatment of non-melanoma skin cancers in the absence of Mohs micrographic surgery","volume":"8","author":"Ferry","year":"2020","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"2026052522575014900_llag003-B6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4103\/JCAS.JCAS_174_18","article-title":"Who should carry out skin cancer excisions? 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