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This highlights the effectiveness of JAKi in treating AA associated with genetic disease as well as sporadic AA.<\/jats:p>","DOI":"10.1093\/ced\/llag022","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T12:36:22Z","timestamp":1768048582000},"page":"1291-1292","source":"Crossref","is-referenced-by-count":0,"title":["Overcoming genetic drivers in alopecia areata: hair regrowth in a patient with\n                    <i>AIRE<\/i>\n                    gene mutation (autoimmune polyendocrinopathy\u2013candidiasis\u2013ectodermal dystrophy, APECED syndrome) treated with ruxolitinib"],"prefix":"10.1093","volume":"51","author":[{"given":"James","family":"Irvine","sequence":"first","affiliation":[{"name":"Department of Dermatology, Glasgow Royal Infirmary, NHS GGC , Glasgow ,","place":["UK"]},{"name":"University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Glasgow Royal Infirmary, NHS GGC , Glasgow ,","place":["UK"]},{"name":"University of Glasgow , Glasgow ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"2026062510014989000_llag022-B1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/imr.12714","article-title":"Lessons from primary immunodeficiencies: autoimmune regulator and autoimmune polyendocrinopathy\u2013candidiasis\u2013ectodermal dystrophy","volume":"287","author":"Constantine","year":"2019","journal-title":"Immunol Rev"},{"key":"2026062510014989000_llag022-B2","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1056\/NEJMoa2312665","article-title":"The role of interferon-\u03b3 in autoimmune polyendocrine syndrome type 1","volume":"390","author":"Oikonomou","year":"2024","journal-title":"N Engl J Med"},{"key":"2026062510014989000_llag022-B3","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1046\/j.1523-1747.1999.00778.x","article-title":"Antibodies against hair follicles are associated with alopecia totalis in autoimmune polyendocrine syndrome type I","volume":"113","author":"Hedstrand","year":"1999","journal-title":"J Invest Dermatol"},{"key":"2026062510014989000_llag022-B4","doi-asserted-by":"crossref","first-page":"e757","DOI":"10.1210\/clinem\/dgae211","article-title":"Lessons from prospective longitudinal follow-up of a French APECED cohort","volume":"110","author":"Humbert","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"key":"2026062510014989000_llag022-B5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10875-023-01629-x","article-title":"Ruxolitinib rescues multiorgan clinical autoimmunity in patients with APS-1","volume":"44","author":"L\u00e9vy","year":"2023","journal-title":"J Clin Immunol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llag022\/66398935\/llag022.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/51\/7\/1291\/66398935\/llag022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/51\/7\/1291\/66398935\/llag022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:01:54Z","timestamp":1782396114000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/51\/7\/1291\/8424713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,13]]},"references-count":5,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,1,13]]},"published-print":{"date-parts":[[2026,6,25]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llag022","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,1,13]]}}}