{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T03:04:07Z","timestamp":1779764647046,"version":"3.53.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic lymphocytic leukaemia (CLL) is the most common type of leukaemia in adults. Skin involvement by malignant CLL cells, or leukaemia cutis, typically presents as localized or generalized papulonodular lesions. We report a series of five patients with CLL who presented with perniosis-like skin findings on the ears, nose and\/or digits. Histopathological analysis of seven skin specimens from these five patients showed a relatively dense, nodular to diffuse, pandermal infiltrate of monomorphic lymphocytes, compatible with CLL. The typical histopathological findings of perniosis, such as a robust perivascular and peri-eccrine infiltrate, dermal oedema and interface change, were absent. In one patient, the skin findings heralded the diagnosis of CLL. In most patients, the skin lesions tended to improve with systemic treatment of the patient\u2019s underlying CLL. We suggest the term \u2018leukaemic pernio\u2019 for leukaemia cutis that clinically mimics perniosis.<\/jats:p>","DOI":"10.1093\/ced\/llag030","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:00:00Z","timestamp":1769086800000},"page":"1061-1065","source":"Crossref","is-referenced-by-count":0,"title":["\u2018Leukaemic pernio\u2019: perniosis-like presentations of chronic lymphocytic leukaemia"],"prefix":"10.1093","volume":"51","author":[{"given":"Aubre","family":"Gilbert","sequence":"first","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine , Stanford, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atif","family":"Saleem","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine , Stanford, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn H","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Stanford University School of Medicine , Redwood City, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S","family":"Khodadoust","sequence":"additional","affiliation":[{"name":"Department of Oncology, Stanford University School of Medicine , Stanford, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9099-7227","authenticated-orcid":false,"given":"Ryanne A","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine , Stanford, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto\u00a0A","family":"Novoa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine , Stanford, CA ,","place":["USA"]},{"name":"Department of Dermatology, Stanford University School of Medicine , Redwood City, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-2471","authenticated-orcid":false,"given":"Kerri E","family":"Rieger","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University School of Medicine , Stanford, CA ,","place":["USA"]},{"name":"Department of Dermatology, Stanford University School of Medicine , Redwood City, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"2026052522570084100_llag030-B1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/ajh.27546","article-title":"Chronic lymphocytic leukemia: 2025 update on the epidemiology, pathogenesis, diagnosis, and therapy","volume":"100","author":"Hallek","year":"2025","journal-title":"Am J 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A possible association with chronic myelomonocytic leukemia","volume":"121","author":"Kelly","year":"1985","journal-title":"Arch Dermatol"},{"key":"2026052522570084100_llag030-B10","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s12185-020-02978-8","article-title":"Cutaneous manifestations of B-cell chronic lymphocytic leukemia","volume":"112","author":"Morozova","year":"2020","journal-title":"Int J Hematol"},{"key":"2026052522570084100_llag030-B11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12895-015-0032-z","article-title":"Small lymphocytic lymphoma with florid perniosis-like features: a case report","volume":"15","author":"Morris","year":"2015","journal-title":"BMC Dermatol"},{"key":"2026052522570084100_llag030-B12","article-title":"Leukemia cutis in a patient with chronic lymphocytic leukemia presenting as bilateral helical nodules","volume":"4","author":"Raufi","year":"2016","journal-title":"SAGE Open Med Case Rep"},{"key":"2026052522570084100_llag030-B13","first-page":"80","article-title":"Ear lobe involvement in chronic lymphocytic leukemia","volume":"11","author":"Koletsa","year":"2013","journal-title":"J Dtsch Dermatol Ges"},{"key":"2026052522570084100_llag030-B14","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1001\/archderm.147.12.1443-a","article-title":"Asymptomatic cauliflower ears in a 73-year-old man. Diagnosis: leukemia cutis in the setting of indolent B-cell chronic lymphocytic leukemia (BCLL)","volume":"147","author":"Kim","year":"2011","journal-title":"Arch Dermatol"},{"key":"2026052522570084100_llag030-B15","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1365-2133.2006.07129.x","article-title":"Chronic lymphocytic leukaemia skin infiltrates affecting prominent parts of the face and the scalp","volume":"154","author":"Jasim","year":"2006","journal-title":"Br J Dermatol"},{"key":"2026052522570084100_llag030-B16","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3892\/etm.2015.2178","article-title":"Cutaneous manifestations in a patient with chronic lymphocytic leukemia involving the head, neck and distal extremities","volume":"9","author":"Lu","year":"2015","journal-title":"Exp Ther Med"},{"key":"2026052522570084100_llag030-B17","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1111\/pde.13366","article-title":"Pernio as the presenting sign of blast crisis in acute lymphoblastic leukemia","volume":"35","author":"Park","year":"2018","journal-title":"Pediatr Dermatol"},{"key":"2026052522570084100_llag030-B18","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1034\/j.1600-0560.2002.290303.x","article-title":"Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia (B-CLL) at sites typical for Borrelia burgdorferi infection","volume":"29","author":"Cerroni","year":"2002","journal-title":"J Cutan Pathol"},{"key":"2026052522570084100_llag030-B19","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/jvc2.368","article-title":"Rare cutaneous manifestation of B-cell chronic lymphocytic leukaemia involving the toes","volume":"3","author":"Costa Blasco","year":"2024","journal-title":"JEADV Clin Pract"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llag030\/66549002\/llag030.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/51\/6\/1061\/66549002\/llag030.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/51\/6\/1061\/66549002\/llag030.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T02:57:13Z","timestamp":1779764233000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/51\/6\/1061\/8439093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,23]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,1,23]]},"published-print":{"date-parts":[[2026,5,26]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llag030","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,1,23]]}}}