{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:49:03Z","timestamp":1782398943070,"version":"3.54.5"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Post-inflammatory hyperpigmentation (PIH) is a common complication following trauma or cutaneous inflammation, particularly affecting individuals with skin of colour. Tranexamic acid (TXA) is a lysine analogue with antifibrinolytic properties and has been used as an off-label agent for melasma and procedural PIH. This pilot study evaluated the efficacy of oral TXA in the prevention and treatment of PIH using a validated in vivo model. A baseline site was treated with 30% trichloroacetic acid to induce PIH (control). Once PIH developed, another site was induced and patients started oral TXA 650\u2005mg for 4 weeks. Both sites were assessed for pigmentation changes at day 56 using standardized photography, Investigator Global Assessment, colorimetry and digital reflectance spectroscopy. While trends toward reduced pigmentation were observed in the TXA-prevention group, none reached statistical significance. Oral TXA may play a role in preventing PIH but did not significantly reduce pigmentation in established PIH lesions.<\/jats:p>","DOI":"10.1093\/ced\/llag082","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:31:25Z","timestamp":1771331485000},"page":"1272-1275","source":"Crossref","is-referenced-by-count":1,"title":["The efficacy of tranexamic acid in prevention and treatment of post-inflammatory hyperpigmentation: a\u00a0pilot study"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4416-9724","authenticated-orcid":false,"given":"Mavra","family":"Masood","sequence":"first","affiliation":[{"name":"Department of Dermatology, VCU Health System , Richmond, VA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Henry Ford Jackson Hospital , Jackson, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalal","family":"Maghfour","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3116-3737","authenticated-orcid":false,"given":"Marissa","family":"Ceresnie","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Lake Granbury Medical Center , Dallas, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Mokhtari","sequence":"additional","affiliation":[{"name":"Oakland University William Beaumont School of Medicine , Auburn Hills, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Redina","family":"Bardhi","sequence":"additional","affiliation":[{"name":"Reveal Research Institute , Dallas, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indermeet","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Medicine, Michigan State University , East Lansing, MI ,","place":["USA"]},{"name":"Department of Physics and Astronomy, Wayne State University , Detroit, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ozog","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Medicine, Michigan State University , East Lansing, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasneem F","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Henry Ford Health , Detroit, MI ,","place":["USA"]},{"name":"Department of Medicine, Michigan State University , East Lansing, MI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"2026062510023124000_llag082-B1","first-page":"20","article-title":"Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color","volume":"3","author":"Davis","year":"2010","journal-title":"J Clin Aesthet Dermatol"},{"key":"2026062510023124000_llag082-B2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s40257-017-0333-6","article-title":"Postinflammatory hyperpigmentation: epidemiology, clinical presentation, pathogenesis and treatment","volume":"19","author":"Kaufman","year":"2018","journal-title":"Am J Clin Dermatol"},{"key":"2026062510023124000_llag082-B3","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/B978-0-323-83144-4.00028-9","volume-title":"Cosmetic Procedures in Skin of Color","author":"Franco","year":"2025"},{"key":"2026062510023124000_llag082-B4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jaad.2017.01.035","article-title":"Chaowattanapanit S et al Post\u00adinflammatory hyperpigmentation: a comprehensive overview. 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