{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:27:51Z","timestamp":1786987671280,"version":"build-2736575974"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Palisaded and interstitial granulomatous dermatoses (PIGDs) are a spectrum of presumed reactive cutaneous disorders sometimes associated with underlying diseases, notably malignant haemopathies. Specific associations between some of these dermatoses and particular haematological neoplasms may exist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the spectrum of haematological neoplasms associated with PIGDs and to establish whether specific associations exist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective monocentric study of all cases of patients with PIGD associated with haematological neoplasms seen in our department and undertook a systematic literature review. Clinical and pathological data were extracted from patient files and articles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 146 cases\u00a0were identified (31 from our institution, 115 from the literature review). Granuloma annulare (N = 76) and elastolytic giant cell granulomas (N = 9) were mainly associated with B- and T-cell lymphoid neoplasms (59\/85, 69%). Four patients with necrobiosis lipoidica were identified, of which two were associated with plasma cell dyscrasias. Interstitial granulomatous dermatitis (N = 22) was associated in half of patients with myeloid neoplasms (n = 11). This association was even stronger (n = 11, 65%) for palisaded neutrophilic granulomatous dermatitis (N = 17), especially with chronic myelomonocytic leukaemia (n = 8, 47%). We also identified 18 patients with unclassified granulomatous dermatoses that were most often associated with lymphoid neoplasm (n = 10, 56%). Medical history and clinical course data suggestive of a link that was not coincidental were identified in 41 of 146 patients (28.1%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This work shows that some PIGD appear to be specifically associated with certain types of haematological neoplasms. The pathophysiological basis of these associations remains to be elucidated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ced\/llag151","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T11:44:49Z","timestamp":1775648689000},"page":"1669-1674","source":"Crossref","is-referenced-by-count":0,"title":["Association between palisaded and interstitial granulomatous dermatoses and haematological neoplasms: evidence beyond coincidence?"],"prefix":"10.1093","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7656-5760","authenticated-orcid":false,"given":"Syna","family":"Hamani","sequence":"first","affiliation":[{"name":"Clinique dermatologique, Universit\u00e9 de Strasbourg et H\u00f4pitaux Universitaires de Strasbourg , Strasbourg ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"S\u00e9verac","sequence":"additional","affiliation":[{"name":"Service de\u00a0Sant\u00e9 Publique, Groupe M\u00e9thodes en Recherche Clinique (GMRC), Universit\u00e9 de Strasbourg et H\u00f4pitaux Universitaires de Strasbourg , Strasbourg ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Cribier","sequence":"additional","affiliation":[{"name":"Clinique dermatologique, Universit\u00e9 de Strasbourg et H\u00f4pitaux Universitaires de Strasbourg , Strasbourg ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lipsker","sequence":"additional","affiliation":[{"name":"Clinique dermatologique, Universit\u00e9 de Strasbourg et H\u00f4pitaux Universitaires de Strasbourg , Strasbourg ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Lenormand","sequence":"additional","affiliation":[{"name":"Clinique dermatologique, Universit\u00e9 de Strasbourg et H\u00f4pitaux Universitaires de Strasbourg , Strasbourg ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"2026081712360661500_llag151-B1","author":"Cribier"},{"key":"2026081712360661500_llag151-B2","volume-title":"Weedon\u2019s Skin Pathology","author":"Patterson","year":"2021","edition":"5th edn"},{"key":"2026081712360661500_llag151-B3","author":"Saurat"},{"key":"2026081712360661500_llag151-B4","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1111\/jdv.18511","article-title":"Reactive granulomatous dermatitis: lumping terms to split confusion","volume":"36","author":"Rosenbach","year":"2022","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2026081712360661500_llag151-B5","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.2022015850","article-title":"International Consensus Classification of myeloid neoplasms and acute leukaemias: integrating morphologic, clinical, and genomic data","volume":"140","author":"Arber","year":"2022","journal-title":"Blood"},{"key":"2026081712360661500_llag151-B6","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1182\/blood.2022015851","article-title":"The International Consensus Classification of mature lymphoid neoplasms: a report from the Clinical Advisory Committee","volume":"140","author":"Campo","year":"2022","journal-title":"Blood"},{"key":"2026081712360661500_llag151-B7","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization Classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukaemia"},{"key":"2026081712360661500_llag151-B8","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization Classification of haematolymphoid tumours: lymphoid neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukaemia"},{"key":"2026081712360661500_llag151-B9","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.jaad.2023.12.028","article-title":"Granuloma annulare is associated with an increased risk of haematologic malignancies: a multicenter cohort study using TriNetX","volume":"90","author":"Garate","year":"2024","journal-title":"J Am Acad Dermatol"},{"key":"2026081712360661500_llag151-B10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1159\/000527461","article-title":"Underlying systemic diseases in interstitial granulomatous dermatitis and palisaded neutrophilic granulomatous dermatitis: a systematic review","volume":"239","author":"Yang","year":"2023","journal-title":"Dermatology"},{"key":"2026081712360661500_llag151-B11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-0560.1998.tb01709.x","article-title":"Cutaneous infiltrate of chronic lymphocytic leukaemia and relationship to primary cutaneous epithelial neoplasms","volume":"25","author":"Smoller","year":"1998","journal-title":"J Cutan Pathol"},{"key":"2026081712360661500_llag151-B12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/jdv.13847","article-title":"Monoclonal gammopathy of cutaneous significance: review of a relevant concept","volume":"31","author":"Lipsker","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2026081712360661500_llag151-B13","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s00277-018-3472-9","article-title":"Autoimmune manifestations associated with myelodysplastic syndromes","volume":"97","author":"Grignano","year":"2018","journal-title":"Ann Hematol"},{"key":"2026081712360661500_llag151-B14","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1002\/acr.20504","article-title":"Systemic and immune manifestations in myelodysplasia: a multicenter retrospective study","volume":"63","author":"de Hollanda","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2026081712360661500_llag151-B15","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/cup.14638","article-title":"Granulomatous dermatitis in the context of chronic myelomonocytic leukemia: more than just reactive infiltrates. An illustrative case report with literature review","volume":"51","author":"Garc\u00eda-Garc\u00eda","year":"2024","journal-title":"J Cutan Pathol"},{"key":"2026081712360661500_llag151-B16","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1097\/DAD.0000000000003087","article-title":"Palisaded neutrophilic and granulomatous dermatitis associated with ASXL1 \u2013 mutated chronic myelomonocytic leukemia: a case report and literature review","volume":"47","author":"Elsharawi","year":"2025","journal-title":"Am J Dermatopathol"},{"key":"2026081712360661500_llag151-B17","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1056\/NEJMoa2026834","article-title":"Somatic mutations in UBA1 and severe adult-onset autoinflammatory disease","volume":"383","author":"Beck","year":"2020","journal-title":"N Engl J Med"},{"key":"2026081712360661500_llag151-B18","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jamadermatol.2021.3344","article-title":"UBA1 variations in neutrophilic dermatosis skin lesions of patients with VEXAS syndrome","volume":"157","author":"Zakine","year":"2021","journal-title":"JAMA Dermatol"},{"key":"2026081712360661500_llag151-B19","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1111\/ijd.15916","article-title":"Atypical extensive lupus tumidus-like eruption as an early presentation of VEXAS syndrome","volume":"61","author":"Ribereau-Gayon","year":"2022","journal-title":"Int J Dermatol"},{"key":"2026081712360661500_llag151-B20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1365-2230.1993.tb01031.x","article-title":"Disseminated cutaneous granulomatous eruptions associated with myelodysplastic syndrome and acute myeloid leukaemia","volume":"18","author":"Vestey","year":"1993","journal-title":"Clin Exp Dermatol"},{"key":"2026081712360661500_llag151-B21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0190-9622(98)70548-1","article-title":"Granuloma annulare mimicking septic emboli in a child with myelodysplastic syndrome","volume":"38","author":"Jones","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"2026081712360661500_llag151-B22","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1200\/JCO.2009.23.0409","article-title":"Granuloma annulare heralding angioimmunoblastic T-cell lymphoma in a patient with a history of epstein-barr virus-associated B-cell lymphoma","volume":"27","author":"Martin","year":"2009","journal-title":"J Clin Oncol"},{"key":"2026081712360661500_llag151-B23","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-2230.2008.02730.x","article-title":"Widespread granuloma annulare and Hodgkin\u2019s disease","volume":"33","author":"Dadban","year":"2008","journal-title":"Clin Exp Dermatol"},{"key":"2026081712360661500_llag151-B24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/ced.13373","article-title":"Malignancy-associated generalized perforating granuloma annulare","volume":"43","author":"Satta","year":"2018","journal-title":"Clin Exp Dermatol"},{"key":"2026081712360661500_llag151-B25","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0190-9622(94)70133-4","article-title":"Granuloma annulare in patients with malignant lymphoma: clinicopathologic study of thirteen new cases","volume":"31","author":"Barksdale","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"2026081712360661500_llag151-B26","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/j.1600-0560.2012.01967.x","article-title":"Granuloma annulare-like eruption associated with B-cell chronic lymphocytic leukemia","volume":"39","author":"Sokumbi","year":"2012","journal-title":"J Cutan Pathol"},{"key":"2026081712360661500_llag151-B27","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/DAD.0b013e318166ea1a","article-title":"Generalized granuloma annulare as an initial manifestation of chronic myelomonocytic leukemia: a report of 2 cases","volume":"30","author":"Hinckley","year":"2008","journal-title":"Am J Dermatopathol"},{"key":"2026081712360661500_llag151-B28","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jaad.2008.11.014","article-title":"Granuloma annulare-like skin lesions as an initial manifestation in a Japanese patient with adult T-cell leukemia\/lymphoma","volume":"60","author":"Kawakami","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"2026081712360661500_llag151-B29","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1684\/ejd.2016.2806","article-title":"Generalised granuloma annulare associated with myelodysplastic syndrome","volume":"26","author":"Maehara","year":"2016","journal-title":"Eur J Dermatol"},{"key":"2026081712360661500_llag151-B30","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.5070\/D3269050159","article-title":"Granuloma annulare-like eruption in chronic lymphocytic leukemia","volume":"26","author":"Hadian","year":"2020","journal-title":"Dermatol Online J"},{"key":"2026081712360661500_llag151-B31","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1001\/archderm.142.4.532","article-title":"Annular elastolytic giant cell granuloma heralding onset and recurrence of acute myelogenous leukemia","volume":"142","author":"Garg","year":"2006","journal-title":"Arch Dermatol"},{"key":"2026081712360661500_llag151-B32","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1600-0560.2011.01811.x","article-title":"Actinic granuloma occurring in an unusual association with cutaneous B-cell chronic lymphocytic leukemia","volume":"39","author":"Kauffman","year":"2012","journal-title":"J Cutan Pathol"},{"key":"2026081712360661500_llag151-B33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00000372-200302000-00012","article-title":"Granuloma annulare-like infiltrates with concomitant cutaneous involvement by B-cell non-Hodgkin\u2019s lymphoma: report of a case","volume":"25","author":"Fullen","year":"2003","journal-title":"Am J Dermatopathol"},{"key":"2026081712360661500_llag151-B34","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2340\/0001555570164167","article-title":"Adult T cell leukemia accompanied by annular elastolytic giant cell granuloma","volume":"70","author":"Kuramoto","year":"1990","journal-title":"Acta Derm Venereol"},{"key":"2026081712360661500_llag151-B35","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4103\/ijdvl.IJDVL_689_17","article-title":"Ulcerated necrobiosis lipoidica: a cutaneous granulomatous reaction associated with systemic B-cell lymphoma","volume":"84","author":"Mahmoudi","year":"2018","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2026081712360661500_llag151-B36","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2340\/00015555-1827","article-title":"Interstitial granulomatous dermatitis associated with myelodysplastic syndrome - complete clearance under therapy with 5-azacytidine","volume":"94","author":"Patsinakidis","year":"2014","journal-title":"Acta Derm Venereol"},{"key":"2026081712360661500_llag151-B37","doi-asserted-by":"crossref","first-page":"264","DOI":"10.4103\/ijd.IJD_432_17","article-title":"Interstitial granulomatous dermatitis due to a rare myeloproliferative neoplasia","volume":"63","author":"Cases-Merida","year":"2018","journal-title":"Indian J Dermatol"},{"key":"2026081712360661500_llag151-B38","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.humpath.2017.04.010","article-title":"Generalized palisaded neutrophilic and granulomatous dermatitis \u2013 a cutaneous manifestation of chronic myelomonocytic leukemia? A clinical, histopathological, and molecular study of 3 cases","volume":"64","author":"Federmann","year":"2017","journal-title":"Hum Pathol"},{"key":"2026081712360661500_llag151-B39","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1097\/DAD.0000000000002085","article-title":"Unique recognizable histopathologic variant of palisaded neutrophilic and granulomatous dermatitis that is associated with SRSF2-mutated chronic myelomonocytic leukemia: case report and review of the literature","volume":"44","author":"Enescu","year":"2022","journal-title":"Am J Dermatopathol"},{"key":"2026081712360661500_llag151-B40","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/DAD.0000000000002149","article-title":"Granulomatous dermatitis heralding myelodisplastic\/myeloproliferative neoplasms. neoplastic or reactive cells? A study of 2 cases","volume":"44","author":"Prieto-Torres","year":"2022","journal-title":"Am J Dermatopathol"},{"key":"2026081712360661500_llag151-B41","doi-asserted-by":"crossref","first-page":"e217","DOI":"10.1111\/ijd.16089","article-title":"IDH2 R140Q mutation associated with palisaded neutrophilic and granulomatous dermatitis with subsequent development of IDH2-mutated acute myeloid leukemia","volume":"62","author":"Himed","year":"2023","journal-title":"Int J Dermatol"},{"key":"2026081712360661500_llag151-B42","doi-asserted-by":"crossref","first-page":"e241","DOI":"10.1111\/jdv.15504","article-title":"Palisaded neutrophilic and granulomatous dermatitis in a patient with chronic myelomonocytic leukaemia","volume":"33","author":"Kohlmann","year":"2019","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2026081712360661500_llag151-B43","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1097\/DAD.0000000000000016","article-title":"Disseminated noninterstitial granulomatous dermatitis as a cutaneous manifestation of the preleukemic state in a patient with myelodysplasia and ulcerative colitis \u2013 apropos a case and review of the literature","volume":"36","author":"Aung","year":"2014","journal-title":"Am J Dermatopathol"},{"key":"2026081712360661500_llag151-B44","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1684\/ejd.2016.2812","article-title":"Disseminated granulomatous skin lesions associated with myelodysplastic syndrome treated successfully with tranilast: a case report and review of the literature","volume":"26","author":"Yoneta","year":"2016","journal-title":"Eur J Dermatol"},{"key":"2026081712360661500_llag151-B45","first-page":"22","article-title":"Disseminated cutaneous granulomatous eruption occurring in the setting of myelodysplasia","volume":"9","author":"Katz","year":"2003","journal-title":"Dermatol Online J"},{"key":"2026081712360661500_llag151-B46","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1001\/archderm.1986.01660230095019","article-title":"Sarcoidal reaction to lymphoma presenting as granulomatous rosacea","volume":"122","author":"Sherertz","year":"1986","journal-title":"Arch Dermatol"},{"key":"2026081712360661500_llag151-B47","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1346-8138.2004.tb00588.x","article-title":"Erythema nodosum and granulomatous lesions preceding acute myelomonocytic leukemia","volume":"31","author":"Anan","year":"2004","journal-title":"J Dermatol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llag151\/68021417\/llag151.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/51\/9\/1669\/68021417\/llag151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/51\/9\/1669\/68021417\/llag151.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:36:19Z","timestamp":1786984579000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/51\/9\/1669\/8650806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,9]]},"references-count":47,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,4,9]]},"published-print":{"date-parts":[[2026,8,17]]}},"URL":"https:\/\/doi.org\/10.1093\/ced\/llag151","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,4,9]]}}}