{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:27:13Z","timestamp":1786987633568,"version":"build-2736575974"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clinical management of Stevens\u2013Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and other immune-mediated cutaneous reactions can benefit from early diagnosis and novel therapeutics. To identify reliable and potential pathogenic biomarkers of SJS\/TEN, we analysed plasma cytokine\/chemokine profiles during the first week of hospitalization. In total, 12 patients with SJS\/TEN and 24 with burns participated in the study. The SJS\/TEN group showed a significant increase in four cytokines throughout the study period. Median concentrations of CXCL10, CXCL9, CXCL11 and tumour necrosis factor-\u03b1 on the first day of hospitalization were 147-, 36.8-, 10.7- and 5.9-fold higher, respectively, in the\u00a0SJS\/TEN group compared with the burns group (P &amp;lt; 0.01). Receiver operating characteristic analysis of these cytokines showed the highest areas under the curve with values of 0.962, 0.955, 1.000 and 0.972, respectively. The early appearance and a sustained large magnitude of changes in these cytokines indicate potential diagnostic and therapeutic utility of the identified cytokines\/chemokines.<\/jats:p>","DOI":"10.1093\/ced\/llag153","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T11:44:50Z","timestamp":1775648690000},"page":"1689-1692","source":"Crossref","is-referenced-by-count":0,"title":["Plasma cytokine and chemokine profile in patients who are hospitalized with toxic epidermal necrolysis"],"prefix":"10.1093","volume":"51","author":[{"given":"Andrew","family":"Anklowitz","sequence":"first","affiliation":[{"name":"Dwight D Eisenhower Army Medical Center , Fort Gordon, GA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Poloni","sequence":"additional","affiliation":[{"name":"Dwight D Eisenhower Army Medical Center , Fort Gordon, GA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7892-5025","authenticated-orcid":false,"given":"Justin","family":"Hale","sequence":"additional","affiliation":[{"name":"Dwight D Eisenhower Army Medical Center , Fort Gordon, GA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Aranda","sequence":"additional","affiliation":[{"name":"Dwight D Eisenhower Army Medical Center , Fort Gordon, GA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Kumar","sequence":"additional","affiliation":[{"name":"Dwight D Eisenhower Army Medical Center , Fort Gordon, GA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Wilson","sequence":"additional","affiliation":[{"name":"Joseph M. Still Research Foundation, Inc. , Augusta, GA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Quinn","sequence":"additional","affiliation":[{"name":"Joseph M. Still Research Foundation, Inc. , Augusta, GA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4332-6719","authenticated-orcid":false,"given":"Balakrishna M","family":"Prasad","sequence":"additional","affiliation":[{"name":"US Army Graduate Program in Anesthesia Nursing , Fort Sam Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"2026081712360699700_llag153-B1","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/jid.2012.510","article-title":"Comprehensive survival analysis of a cohort of patients with Stevens\u2013Johnson syndrome and toxic epidermal necrolysis","volume":"133","author":"Sekula","year":"2013","journal-title":"J Invest 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diagnosis and management","volume":"25","author":"Shah","year":"2024","journal-title":"Am J Clin Dermatol"},{"key":"2026081712360699700_llag153-B5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1076029620950831","article-title":"The role of IL-13, IL-15 and granulysin in the pathogenesis of Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis","volume":"27","author":"Sadek","year":"2021","journal-title":"Clin Appl Thromb Hemost"},{"key":"2026081712360699700_llag153-B6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1684\/ejd.2014.2477","article-title":"Differential expression profile of Th1\/Th2-associated chemokines characterizes Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis (SJS\/TEN) and drug-induced hypersensitivity syndrome\/drug reaction with eosinophilia and systemic symptoms (DIHS\/DRESS) as distinct entities","volume":"25","author":"Miyagawa","year":"2015","journal-title":"Eur J 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immunomodulating therapies: a systematic review and network meta-analysis","volume":"84","author":"Tsai","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"2026081712360699700_llag153-B10","doi-asserted-by":"crossref","first-page":"10733","DOI":"10.1038\/s41467-024-54180-7","article-title":"Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade","volume":"15","author":"Chen","year":"2024","journal-title":"Nat Commun"}],"container-title":["Clinical and Experimental 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