{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:23:44Z","timestamp":1783520624639,"version":"3.55.0"},"reference-count":108,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021515","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021515","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prurigo nodularis (PN) is a chronic, highly pruritic inflammatory skin disease that, until recently, was poorly understood. PN was first described in the late 1800s, but awareness of the disease remained low, probably because of its low prevalence and resemblance to other diseases. Interest in the research and therapeutic advancement of PN has grown in recent years, leading to a greater understanding by the medical community of its natural history, pathophysiology, diagnosis and treatment. We describe how our understanding of PN has evolved in recent years and how current therapeutic advancements have facilitated a greater appreciation of PN as a unique disease with a distinct pathophysiology.<\/jats:p>","DOI":"10.1093\/ced\/llag223","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:04:14Z","timestamp":1783519454000},"source":"Crossref","is-referenced-by-count":0,"title":["The evolving understanding of prurigo nodularis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3736-1515","authenticated-orcid":false,"given":"Shawn G","family":"Kwatra","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]},{"name":"Maryland Itch Center, University of Maryland School of Medicine , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9546-4273","authenticated-orcid":false,"given":"Brian S","family":"Kim","sequence":"additional","affiliation":[{"name":"Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai , New York, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Bewley","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust , London ,","place":["UK"]},{"name":"Queen Mary University of London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarina B","family":"Elmariah","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California San Francisco , San Francisco, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Zahn","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc. , Tarrytown, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simmi","family":"Wiggins","sequence":"additional","affiliation":[{"name":"Sanofi , Reading ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"2026070810040824800_llag223-B1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2340\/00015555-2774","article-title":"Chronic prurigo of nodular type: a review","volume":"98","author":"Zeidler","year":"2018","journal-title":"Acta Derm Venereol"},{"key":"2026070810040824800_llag223-B2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jaad.2020.07.025","article-title":"Practical approaches for diagnosis and management of prurigo nodularis: United States expert panel consensus","volume":"84","author":"Elmariah","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"2026070810040824800_llag223-B3","volume-title":"A Practical Treatise on Disease of the Skin for the Use of Students and 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